In the realm of peptide synthesis and advanced organic chemistry, certain reagents stand out for their indispensable contributions to reaction efficiency and product quality. 1-Hydroxy-7-azabenzotriazole, commonly referred to as HOAt and identified by CAS number 39968-33-7, is one such critical compound. Understanding its properties and knowing where to source it from trusted manufacturers is paramount for chemists aiming for success in their synthetic endeavors.

HOAt is primarily utilized as a peptide coupling additive. Its efficacy stems from its ability to significantly suppress racemization, a common issue in peptide bond formation that can lead to a mixture of enantiomers. By minimizing the inversion of chiral centers, HOAt ensures higher purity and stereochemical integrity of the synthesized peptides. This is crucial for biologically active peptides where even minor deviations can affect therapeutic efficacy or lead to unwanted side effects. For researchers and manufacturers, the ability to buy HOAt means achieving more reliable and reproducible synthesis outcomes.

The key properties of HOAt include its fine crystalline powder appearance, typically white to off-white, and a high purity level, often exceeding 99% as determined by HPLC analysis. This high purity is essential for its demanding applications in sensitive chemical reactions. When you purchase HOAt, ensuring this level of purity from your supplier is a non-negotiable aspect of quality assurance.

Beyond its role in peptide synthesis, HOAt also finds applications in other areas of organic synthesis where acylation or similar bond formations are required, acting as a potent activator and enhancer. The consistent quality provided by reputable manufacturers is what makes HOAt such a valuable tool across various chemical disciplines.

For professionals looking to procure HOAt, identifying reliable suppliers is a critical step. Manufacturers and suppliers who provide comprehensive documentation, such as Certificates of Analysis (CoA) and Safety Data Sheets (SDS), alongside consistent product quality and competitive pricing, are ideal partners. Sourcing from established chemical hubs, like China, often provides access to advanced manufacturing capabilities and a broad selection of high-purity reagents. Therefore, when you need to buy HOAt, consider suppliers that demonstrate a strong commitment to quality and customer support.

In conclusion, 1-Hydroxy-7-azabenzotriazole (CAS 39968-33-7) is a vital reagent for achieving high-quality peptide synthesis and efficient organic transformations. Understanding its properties and prioritizing procurement from dependable manufacturers and suppliers ensures that chemists can effectively utilize this powerful additive to drive their research and development forward.