In the intricate world of pharmaceutical manufacturing, the selection and procurement of chemical intermediates are critical to the success of drug development and production. Among these vital compounds is 10-Propargyl-10-deazaaminopterin, known in the pharmaceutical realm as Pralatrexate and identified by CAS number 146464-95-1. This molecule serves as a cornerstone for advanced therapies, particularly in the oncology sector, making it a high-demand product for pharmaceutical companies and research institutions.

As a leading supplier and manufacturer of fine chemicals, we recognize the strategic importance of intermediates like 10-Propargyl-10-deazaaminopterin. Its unique pharmacological properties as a potent antifolate and dihydrofolate reductase (DHFR) inhibitor make it indispensable for certain therapeutic applications, most notably in the treatment of specific types of lymphoma.

The Crucial Role of 10-Propargyl-10-deazaaminopterin:

10-Propargyl-10-deazaaminopterin is not just another chemical compound; it is a key building block in the creation of life-saving medications. Its efficacy stems from its ability to interfere with folate metabolism, a fundamental process for cell division and growth. By inhibiting DHFR, Pralatrexate effectively chokes off the supply of essential nucleotides required by rapidly dividing cells, such as cancer cells.

  • Targeted Therapy: Its specific mechanism of action allows for targeted disruption of cancer cell machinery, minimizing damage to healthy tissues when formulated correctly.
  • Research and Development: For R&D scientists, access to high-purity 10-Propargyl-10-deazaaminopterin is essential for preclinical studies, mechanism of action investigations, and the development of next-generation antifolate drugs.
  • API Synthesis: It is directly used in the synthesis of the Pralatrexate API, a drug approved for specific hematological malignancies. This makes its availability from reliable manufacturers critical for commercial drug production.

Sourcing Best Practices for Procurement Managers:

When looking to buy 10-Propargyl-10-deazaaminopterin, procurement professionals should prioritize:

  • Supplier Verification: Partner with manufacturers that provide comprehensive documentation, including Certificates of Analysis (CoA), and adhere to Good Manufacturing Practices (GMP) or equivalent quality standards.
  • Purity and Consistency: Ensure the material consistently meets specified purity levels (e.g., ≥98%). Batch-to-batch consistency is vital for reproducible drug formulation and efficacy.
  • Supply Chain Reliability: Establish relationships with suppliers who have a proven track record of stable production and timely delivery. Understanding their capacity and logistics is key.
  • Competitive Pricing: Obtain multiple quotes to compare pricing for bulk purchases and understand the value proposition offered by different suppliers, factoring in quality and reliability.

As a dedicated supplier of 10-Propargyl-10-deazaaminopterin, we offer both research-grade and bulk quantities, backed by rigorous quality assurance and a commitment to customer service. Engaging with our team allows you to secure a dependable source for this critical pharmaceutical intermediate, facilitating your ongoing pharmaceutical development and manufacturing efforts.