The landscape of chemical innovation is constantly evolving, with specialty fluorinated compounds playing an increasingly significant role across various industries. Among these, 1,2,3-Trifluorobenzene (CAS 1489-53-8) emerges as a vital intermediate, prized for its unique structural features and versatile chemical properties. For professionals in R&D, procurement, and manufacturing, understanding this compound—from its fundamental properties to its industrial production and applications—is essential for leveraging its full potential. As a leading manufacturer and supplier, NINGBO INNO PHARMCHEM CO.,LTD. provides crucial insights into this valuable chemical.

Physical and Chemical Characteristics of 1,2,3-Trifluorobenzene

1,2,3-Trifluorobenzene is characterized by its appearance as a clear, colorless to pale yellow liquid, with a mild aromatic odor. Its molecular formula is C6H3F3, and it has a molecular weight of approximately 132.08 g/mol. Key physical properties include a density of about 1.28 g/cm³ at 25°C and a boiling point in the range of 94-95°C. These properties make it manageable for industrial handling and processing, though its flash point of 25°F indicates it is flammable, necessitating appropriate safety precautions. The compound’s high purity, typically ≥99.0%, is a testament to the sophisticated manufacturing processes employed by its producers.

Chemically, the presence of three fluorine atoms significantly influences the benzene ring’s electron density. This electron-withdrawing effect makes 1,2,3-Trifluorobenzene a valuable intermediate in organic synthesis. It can undergo various functionalization reactions, making it a versatile building block for more complex molecules. Its stability and unique electronic profile are particularly beneficial in pharmaceutical applications.

Manufacturing and Quality Assurance

The production of high-purity 1,2,3-Trifluorobenzene involves specialized synthetic routes, often focusing on efficiency, yield, and minimizing isomeric impurities. Manufacturers ensure that the final product meets stringent quality standards, as evidenced by gas chromatography (GC) analysis for assay and Karl Fischer titration for moisture content. Adherence to quality management systems like ISO 9001 is common among reputable suppliers in China, guaranteeing consistency and reliability. Packaging is typically in drums (e.g., 200 kg) or custom containers, with transport classification often noted as non-hazardous, although flammability requires careful handling and storage in cool, well-ventilated areas, away from ignition sources.

Diverse Applications Across Industries

The utility of 1,2,3-Trifluorobenzene spans several critical sectors:

  • Pharmaceutical Intermediates: This is arguably its most prominent application. Fluorinated compounds are frequently employed in drug design to enhance metabolic stability, increase lipophilicity, and improve target binding affinity. 1,2,3-Trifluorobenzene serves as a key starting material for synthesizing numerous fluorinated APIs.
  • Organic Synthesis: As a reactive building block, it facilitates the synthesis of complex organic molecules through various coupling reactions and substitutions, allowing chemists to precisely introduce the trifluorinated moiety.
  • Materials Science: It finds use in the development of advanced materials, including precursors for liquid crystal displays (LCDs) and other electronic materials, where its unique electronic properties are advantageous.
  • Agrochemicals: Similar to pharmaceuticals, fluorination can improve the efficacy and persistence of agrochemicals, making 1,2,3-Trifluorobenzene a useful intermediate in this sector as well.

For businesses seeking to buy 1,2,3-Trifluorobenzene, partnering with a reliable manufacturer and supplier in China, such as NINGBO INNO PHARMCHEM CO.,LTD., is crucial. We offer a commitment to high-purity products, competitive pricing, and stable supply chains, supporting your critical R&D and production needs.