The field of organic chemistry thrives on the availability of versatile building blocks that can be transformed into complex and valuable molecules. Among these, heterocyclic compounds, particularly those derived from indole, hold significant importance. 1,5,6,7-Tetrahydro-4H-indol-4-one, identified by CAS number 13754-86-4, is a prime example of such a compound, serving as a critical intermediate in numerous synthetic routes.

Chemical Profile and Synthesis

1,5,6,7-Tetrahydro-4H-indol-4-one is characterized by its molecular formula C8H9NO and a molecular weight of 135.16 g/mol. Its chemical properties include a melting point of 188-190°C and a boiling point of approximately 311°C. It typically appears as a white to light yellow crystalline powder. While various synthesis routes exist, a common approach involves the reaction of 6,7-dihydro-4(5H)-benzofuranone with ammonia derivatives under specific temperature and solvent conditions, followed by purification steps like column chromatography. As a manufacturer, we focus on optimized synthesis to ensure high purity and yield.

Applications in Organic Synthesis

The utility of 1,5,6,7-Tetrahydro-4H-indol-4-one spans several areas of organic chemistry:

  • Pharmaceutical Intermediate: Its most significant application is as a precursor in the synthesis of pharmaceuticals. It is used in the preparation of compounds like Psammopemmin A, which has shown potential as an antitumor agent. This makes it a highly valuable compound for drug discovery and development laboratories.
  • Heterocyclic Synthesis: The compound is a key reactant for creating a variety of indole derivatives and other fused heterocyclic systems. These structures are often found in biologically active natural products and synthetic drugs.
  • C-H Insertion Reactions: It participates in C-H insertion reactions, allowing for the formation of complex carbocyclic and heterocyclic frameworks, including tricyclic tetrahydrobenzindoles and condensed pyrroloindoles.
  • Research and Development: Organic chemists utilize this intermediate in academic and industrial research to explore novel reaction mechanisms and to synthesize new chemical entities with targeted properties.

Sourcing and Procurement

For researchers and chemical manufacturers looking to buy 1,5,6,7-Tetrahydro-4H-indol-4-one, sourcing from reliable suppliers is crucial. As a dedicated manufacturer and supplier, we ensure that our product meets the required specifications for purity and consistency. We offer this intermediate at competitive prices, making it accessible for various research and production scales. Procurement managers can rely on our efficient logistics and customer support to facilitate their acquisition process. Understanding the product's chemical properties and application scope helps in placing informed purchase orders.

Conclusion

1,5,6,7-Tetrahydro-4H-indol-4-one (CAS 13754-86-4) is a testament to the importance of well-characterized intermediates in advancing organic synthesis. Its diverse applications, particularly in pharmaceutical development, underscore the need for dependable suppliers who can provide this crucial building block. We are committed to supporting scientific innovation by offering high-quality 1,5,6,7-Tetrahydro-4H-indol-4-one to the global chemical community.