In the vast landscape of organic chemistry and industrial synthesis, certain compounds emerge as foundational elements, indispensable for the creation of more complex molecules. 2,4-Dichloropyrimidine, with the CAS number 3934-20-1, is one such compound, playing a critical role as an intermediate in the pharmaceutical and fine chemical sectors. Understanding its chemical properties, synthesis, and manufacturing considerations is crucial for chemists, R&D professionals, and procurement managers.

Understanding the Chemical Profile of 2,4-Dichloropyrimidine

2,4-Dichloropyrimidine is a heterocyclic organic compound characterized by a pyrimidine ring substituted with two chlorine atoms at the 2 and 4 positions. Its molecular formula is C4H2Cl2N2, and its molecular weight is approximately 148.98 g/mol. Typically presented as a white to light yellow or off-white powder or crystalline solid, it possesses a melting point ranging from 57-61°C. The compound is considered moisture-sensitive and exhibits moderate solubility in organic solvents like chloroform and ethyl acetate, as well as partial solubility in water.

Manufacturing and Synthesis Pathways

The synthesis of 2,4-Dichloropyrimidine often begins with uracil (pyrimidine-2,4(1H,3H)-dione). A common method involves the chlorination of uracil using phosphoryl chloride (POCl3) at elevated temperatures, typically around 110°C, often with refluxing for several hours. Following the reaction, purification steps such as distillation to remove excess reagents and extraction with organic solvents, followed by drying and solvent removal, yield the desired product. The ability to efficiently produce high-purity 2,4-Dichloropyrimidine is a testament to advanced chemical manufacturing capabilities.

Key Applications and Industrial Relevance

The primary industrial application of 2,4-Dichloropyrimidine is as a pivotal intermediate in the synthesis of pharmaceuticals. Its reactivity allows for selective substitutions, making it invaluable for creating complex APIs such as Osimertinib (a treatment for specific lung cancers) and Pazopanib (used for renal cell carcinoma and soft tissue sarcoma). Beyond pharmaceuticals, it can also find use in the synthesis of agrochemicals and other specialty organic compounds.

Sourcing Insights for B2B Buyers

For businesses looking to buy 2,4-Dichloropyrimidine, sourcing from reliable manufacturers is paramount. Key considerations include ensuring high purity (≥99% by HPLC), consistent supply, and competitive pricing. Working with established suppliers, particularly those with significant manufacturing capacity in regions like China, can offer advantages in terms of both cost and quality assurance. Always request a Certificate of Analysis (CoA) to verify product specifications before purchase.

Conclusion

2,4-Dichloropyrimidine (CAS 3934-20-1) is a cornerstone intermediate in modern chemical synthesis, particularly for life-saving pharmaceuticals. Understanding its chemical properties and manufacturing processes empowers B2B buyers to make informed sourcing decisions, ensuring the quality and reliability needed for successful production.