Proteins are dynamic molecules, constantly undergoing subtle and significant conformational changes that are central to their function. Understanding these alterations is key in fields ranging from enzymology to disease mechanism research. 2,6-ANS, or 6-Anilinonaphthalene-2-Sulfonic Acid (CAS 20096-53-1), has emerged as an invaluable fluorescent probe for dissecting these dynamic processes.

As a specialized manufacturer and supplier based in China, we provide 2,6-ANS at a stringent 99% purity. This level of purity is essential because the fluorescence output of 2,6-ANS is highly sensitive to its local environment. Even minute variations can lead to misinterpretations when monitoring the delicate conformational shifts within proteins. Our manufacturing process is optimized to ensure that every batch of 2,6-ANS you buy is consistent and reliable.

The principle behind using 2,6-ANS for conformational analysis relies on its environment-sensitive fluorescence. When a protein undergoes a conformational change, the local hydrophobicity, charge distribution, or structural rigidity around the bound 2,6-ANS molecule is altered. These changes directly impact the probe's fluorescence intensity, lifetime, and emission spectrum. For instance, a transition that buries a previously exposed hydrophobic region will lead to enhanced fluorescence from the bound 2,6-ANS.

This property makes 2,6-ANS particularly useful for studying phenomena such as protein unfolding and refolding, allosteric regulation, and ligand binding events. Researchers can observe real-time spectral shifts or changes in fluorescence intensity to map the kinetics and thermodynamics of these conformational transitions. The probe's ability to intercalate into hydrophobic regions makes it ideal for monitoring changes that involve the exposure or sequestration of hydrophobic surfaces.

For organizations involved in pharmaceutical R&D, acquiring high-quality 2,6-ANS from a trusted supplier is a strategic decision. Our role as a manufacturer and supplier in China ensures competitive pricing and a stable supply, allowing research teams to buy the quantities they need without compromising their budget or project timelines. We invite you to contact us to discuss your requirements for this critical fluorescent probe and to receive a detailed quote, ensuring your research into protein dynamics is powered by the best available reagents.