For professionals in the pharmaceutical and fine chemical industries, understanding the fundamental properties and synthesis routes of key intermediates is essential for effective procurement and application. 2-Amino-5-chlorobenzophenone (CAS 719-59-5) is a prime example, serving as a critical building block in the synthesis of numerous sedative and anxiolytic drugs. This article delves into its chemical characteristics and common synthesis methods, offering insights valuable for R&D scientists and procurement managers.

The chemical structure of 2-Amino-5-chlorobenzophenone consists of a benzophenone backbone with an amino group at the 2-position and a chlorine atom at the 5-position of one phenyl ring. This arrangement confers specific reactivity that is leveraged in pharmaceutical synthesis. Its molecular formula is C13H10ClNO, with a molecular weight of approximately 231.68 g/mol. Key physical properties often cited include its appearance as a yellow or bright yellow acicular crystal and a melting point range of 97.0-99.0℃. Its high purity, typically ≥99.0%, is a critical factor for its use as a pharmaceutical intermediate. Buyers often search for '2-amino-5-chlorobenzophenone chemical properties' or 'synthesis of CAS 719-59-5'.

Regarding synthesis, several methods can yield 2-Amino-5-chlorobenzophenone. A common industrial approach involves the reaction of appropriate aniline derivatives with benzoyl chlorides or their equivalents under specific catalytic conditions. Alternative routes might include reductive cyclization or modifications of existing aromatic compounds. The choice of synthesis pathway is often dictated by factors such as raw material availability, reaction efficiency, yield, purity requirements, and scalability for industrial production. The development of cost-effective and high-yield synthesis methods is crucial for manufacturers supplying this intermediate.

As a dedicated supplier of fine chemicals, we provide 2-Amino-5-chlorobenzophenone that meets stringent quality and purity standards. Our manufacturing processes are optimized for efficiency and scalability, ensuring a reliable supply for pharmaceutical companies worldwide. We understand the importance of detailed chemical information for your R&D and production needs. We encourage you to contact us for inquiries about product specifications, pricing for bulk purchases, and sample availability. Partnering with us ensures access to a high-quality intermediate crucial for your pharmaceutical applications.