The relentless pursuit of novel therapeutics in the pharmaceutical industry hinges on the availability of advanced chemical building blocks. Among these, 2-Amino-N-(2,2,2-trifluoroethyl)acetamide hydrochloride (CAS 1171331-39-7) has emerged as a compound of significant importance. Its unique chemical structure, featuring a trifluoroethyl group, offers distinct advantages that are highly valued in drug discovery and development.

The Impact of Fluorine in Pharmaceuticals

The incorporation of fluorine atoms into organic molecules is a well-established strategy in medicinal chemistry. The trifluoroethyl moiety present in 2-Amino-N-(2,2,2-trifluoroethyl)acetamide hydrochloride plays a crucial role in modifying the pharmacokinetic and pharmacodynamic properties of drug candidates. Specifically, it can enhance metabolic stability, increase lipophilicity (aiding cell membrane penetration), and influence binding affinity to target proteins. This makes the compound an attractive intermediate for synthesizing molecules with improved efficacy and duration of action.

Key Applications in Drug Discovery

The primary utility of 2-Amino-N-(2,2,2-trifluoroethyl)acetamide hydrochloride lies in its application as a versatile intermediate. It is extensively used in the synthesis of:

  • Protease Inhibitors: This class of drugs is critical in treating viral infections like HIV and Hepatitis C, as well as various cancers. The structural features of the trifluoroethylacetamide derivative contribute to the potency and selectivity of these inhibitors.
  • Other Novel APIs: Researchers are continually exploring its use in developing new chemical entities for a wide range of therapeutic areas, leveraging its fluorine-rich structure for unique pharmacological profiles.
  • Agrochemicals: Beyond pharmaceuticals, it also finds application in the agrochemical sector as a building block for advanced pesticides, benefiting from the stability and efficacy imparted by the trifluoroethyl group.

Sourcing Considerations for R&D Teams

For pharmaceutical researchers and procurement teams, sourcing high-quality 2-Amino-N-(2,2,2-trifluoroethyl)acetamide hydrochloride is critical. When looking to buy this intermediate, prioritize suppliers who can consistently provide:

  • High Purity (≥98%): Essential for reliable synthesis and accurate experimental results.
  • Consistent Physical Form: Typically a white crystalline powder, ensuring it meets standard specifications.
  • Reliable Supply: Partnering with manufacturers, especially from China, offers scalability and competitive pricing.
  • Technical Support: Access to documentation and responsive customer service is invaluable.

By engaging with reputable chemical manufacturers and suppliers, drug discovery teams can ensure they have access to this vital building block, facilitating the development of next-generation medicines. Investing in quality intermediates like CAS 1171331-39-7 is a cornerstone of successful pharmaceutical innovation.