Understanding the fundamental properties and manufacturing of key chemical intermediates is crucial for anyone involved in pharmaceutical synthesis or fine chemical production. 2-Aminoacetophenone (CAS 551-93-9) is one such compound, widely recognized for its role as a precursor in the synthesis of Linagliptin, an important medication for managing type 2 diabetes. This article explores its chemical characteristics, synthesis methods, and what to look for when sourcing from manufacturers.

Chemical and Physical Properties of 2-Aminoacetophenone

2-Aminoacetophenone, also known by synonyms such as 2-Acetylaniline or o-Aminoacetophenone, is an organic compound with the molecular formula C8H9NO and a molecular weight of approximately 135.16 g/mol. It typically presents as a yellow to yellow-brown liquid. Key physical properties include a melting point around 20°C and a boiling point of approximately 251.8°C at standard atmospheric pressure. Its distinct grape-like odor also makes it a compound of interest in flavor science and analysis. Understanding these properties is vital for its safe handling, storage, and effective application in synthesis.

Synthesis Routes and Manufacturing Considerations

The synthesis of 2-Aminoacetophenone is a specialized process that requires careful control to achieve high purity. Common synthesis pathways often involve reactions such as the cyclization of oximes or reactions utilizing aniline derivatives. Manufacturers focus on optimizing reaction conditions, purification techniques, and process safety to ensure a consistent and high-quality product. For instance, the use of specific solvents, catalysts, and meticulous purification steps like distillation or chromatography are critical to achieving the desired purity levels, often exceeding 98.0%.

The Importance of Purity and Quality from Manufacturers

In the pharmaceutical industry, the purity of starting materials and intermediates directly correlates with the efficacy and safety of the final API. For 2-Aminoacetophenone, suppliers must guarantee stringent purity standards. Manufacturers that employ robust quality control measures, provide detailed analytical data (like CoA), and have experience in supplying to regulated industries are preferred. When you buy 2-Aminoacetophenone, verifying its compliance with industry standards and ensuring a stable supply from a trusted manufacturer is paramount.

Sourcing 2-Aminoacetophenone from China: Benefits and Insights

China has become a leading global supplier of chemical intermediates, including 2-Aminoacetophenone. Manufacturers in China often offer competitive pricing due to large-scale production capabilities and streamlined processes. When sourcing from this region, it is advisable to partner with manufacturers who have a proven track record in exporting, understand international quality requirements, and can provide comprehensive documentation. Engaging with a reputable 2-Aminoacetophenone supplier in China can secure a reliable source for your critical needs.

Applications and Future Outlook

While its primary application is as an intermediate in the synthesis of Linagliptin, 2-Aminoacetophenone also finds use in research laboratories as an analytical standard and in the flavor industry due to its characteristic aroma. As the demand for diabetes management medications continues to grow, the importance of a consistent and high-quality supply of 2-Aminoacetophenone will only increase, underscoring the value of strong partnerships with experienced manufacturers.