For professionals engaged in synthetic chemistry, understanding the nuanced properties of chemical intermediates is fundamental to successful experimentation and production. 2-Bromo-1-chloro-4-fluorobenzene, a meticulously designed aromatic compound, offers a unique combination of chemical attributes that make it indispensable across various industrial applications, most notably in pharmaceuticals and agrochemicals. Its trifunctionalized benzene ring, adorned with bromine, chlorine, and fluorine atoms, dictates its reactivity, solubility, and overall utility in complex chemical transformations.

As a supplier and manufacturer committed to excellence, we provide detailed insights into the properties of our products. For those looking to buy 2-Bromo-1-chloro-4-fluorobenzene, a thorough understanding of its chemical and physical characteristics is key to optimizing its use in their specific synthetic processes. We ensure that our product meets the highest purity standards, typically ≥99.0%, to facilitate reliable and reproducible results.

Molecular Structure and Reactivity

The molecular formula of 2-Bromo-1-chloro-4-fluorobenzene is C6H3BrClF, with a molecular weight of approximately 209.44 g/mol. The strategic positioning of the halogens significantly influences its reactivity. The bromine atom, being the largest and most polarizable, is often the primary site for nucleophilic substitution or oxidative addition in metal-catalyzed reactions, such as palladium-catalyzed cross-couplings (e.g., Suzuki, Heck, Sonogashira). The chlorine and fluorine atoms also play a role; they can modulate the electron density of the aromatic ring, influencing the reactivity at other positions and affecting the properties of the final synthesized molecules.

This differential reactivity allows for selective functionalization, a critical aspect in building complex molecular architectures. For instance, a chemist might first perform a Suzuki coupling at the bromine position, then later engage the chlorine or fluorine in a different type of transformation or use them to fine-tune the electronic or steric properties of the resultant compound.

Physical Characteristics and Handling

In terms of physical properties, 2-Bromo-1-chloro-4-fluorobenzene is typically described as a clear, colorless to light yellow liquid. Its density is around 1.75 g/cm³, indicating it is significantly denser than water. The boiling point is approximately 202.1 °C at standard atmospheric pressure (760 mmHg), and its refractive index is about 1.545. These properties are crucial for chemists when designing reaction conditions, purification methods (like distillation), and storage protocols.

Safe handling and storage are paramount. As a chemical intermediate, it should be stored in a tightly closed container in a cool, dry, and well-ventilated area, away from incompatible substances. Understanding these physical characteristics ensures efficient and safe utilization in laboratory and industrial settings.

Sourcing High-Purity Intermediates

When sourcing 2-Bromo-1-chloro-4-fluorobenzene, it's vital to partner with a reliable supplier that prioritizes product quality and transparency. Our commitment as a manufacturer ensures that you receive a product that adheres to strict purity specifications (≥99.0%). We offer competitive pricing and a stable supply chain, making us an ideal choice for both research and industrial needs. We encourage potential buyers to request a quote and sample to verify the quality and consistency of our offering.