The journey from conceptualizing a new drug to its successful development is a complex, multi-stage process that relies heavily on the availability of specialized chemical intermediates. Among these foundational molecules, 2-Bromo-2,3-dihydro-1H-inden-1-one, identified by its CAS number 1775-27-5, plays a significant role as a versatile building block in the synthesis of novel Active Pharmaceutical Ingredients (APIs).

As a dedicated supplier and manufacturer of fine chemicals, we recognize the immense value of such intermediates in driving pharmaceutical innovation. This article aims to shed light on the importance of 2-Bromo-2,3-dihydro-1H-inden-1-one for R&D scientists and procurement professionals, covering its chemical significance, synthesis, and the benefits of sourcing from a reliable manufacturer.

The Chemical Architecture and Reactivity

2-Bromo-2,3-dihydro-1H-inden-1-one is a structurally rich molecule. Its core indanone skeleton is fused with a benzene ring, and crucially, it features an alpha-bromoketone functionality. This combination of an electrophilic carbon attached to bromine, adjacent to a carbonyl group, renders the molecule highly reactive. The bromine atom can readily be displaced by a wide array of nucleophiles, allowing for the introduction of diverse functional groups. This versatility is key for chemists aiming to construct complex molecular architectures.

Moreover, the presence of the carbonyl group opens avenues for condensation reactions, such as the formation of imines or oximes, further expanding its synthetic utility. The dichloro-substituted aromatic ring provides additional points for modification, particularly through transition metal-catalyzed cross-coupling reactions. This multi-faceted reactivity profile makes 2-Bromo-2,3-dihydro-1H-inden-1-one an exceptionally valuable intermediate for creating novel drug candidates with targeted properties.

Role in API Synthesis and Drug Discovery

The indanone motif itself is prevalent in numerous pharmaceutical agents, contributing to their pharmacological activity. By providing this functionalized indanone, we enable researchers to explore new chemical spaces and develop APIs with enhanced efficacy or novel mechanisms of action. For instance, the molecule can serve as a precursor in the synthesis of kinase inhibitors, antiviral agents, or central nervous system (CNS) active compounds, depending on the subsequent modifications. The ability to reliably buy this intermediate ensures that drug discovery programs can proceed without interruption.

Our manufacturing expertise ensures that the 2-Bromo-2,3-dihydro-1H-inden-1-one we supply is of the highest purity, a critical factor for reproducible and successful synthesis. We employ advanced analytical techniques to confirm its identity and purity, providing researchers with the confidence they need for their sensitive applications.

Securing Your Supply Chain

For procurement managers and R&D teams, establishing a robust supply chain for critical intermediates is paramount. Sourcing from a reputable manufacturer and supplier like us means gaining access to a consistent supply of high-quality 2-Bromo-2,3-dihydro-1H-inden-1-one. We understand the importance of timely delivery and predictable product quality, enabling seamless integration into your research and manufacturing processes.

We encourage scientists and procurement professionals to explore the potential of 2-Bromo-2,3-dihydro-1H-inden-1-one in their projects. We are here to provide the necessary materials and support to help you achieve your pharmaceutical development goals. Contact us today to discuss your requirements and learn how we can be your trusted partner in chemical synthesis.