In the realm of advanced organic synthesis, the availability of specific, functionalized building blocks is paramount. Aryl fluorinated compounds, in particular, have gained significant attention due to the unique properties fluorine imparts to molecules. Among these, 2-Bromo-5-fluorophenol (CAS: 147460-41-1) serves as a prime example of a versatile aryl fluorinated building block with substantial utility.

Understanding the 'Aryl Fluorinated Building Block' Concept

An 'aryl fluorinated building block' refers to an aromatic compound that contains at least one fluorine atom. These molecules are instrumental in organic synthesis because fluorine substitution can profoundly alter a compound's physical, chemical, and biological properties. For instance, fluorine can increase lipophilicity, enhance metabolic stability, and modulate pKa values, all of which are critical considerations in drug discovery and materials science. 2-Bromo-5-fluorophenol fits this description perfectly, offering not only fluorine but also a bromine atom and a reactive hydroxyl group on an aromatic core, providing multiple points for chemical manipulation.

Chemical Properties and Synthesis Applications

2-Bromo-5-fluorophenol is characterized by its clear, colorless to light yellow liquid appearance and a boiling point of approximately 185°C. Its density is around 1.717 g/mL at 25°C. As a synthesis intermediate, its primary value lies in its ability to participate in a variety of reactions. The bromine atom is an excellent leaving group for cross-coupling reactions (e.g., palladium-catalyzed couplings), enabling the formation of new carbon-carbon bonds. This is crucial for constructing complex molecular frameworks. The hydroxyl group can be easily derivatized, for example, through ether formation, introducing further structural diversity. The presence of fluorine influences the electronic nature of the aromatic ring, which can be beneficial for specific reactivity patterns and for tuning the properties of the final products.

Use in Pharmaceutical Intermediates and Beyond

The demand for 2-Bromo-5-fluorophenol is significantly driven by its role as a pharmaceutical intermediate. It is employed in the synthesis of key precursors for active pharmaceutical ingredients (APIs), particularly those involving complex polycyclic structures. Researchers looking to buy this compound for drug development often seek manufacturers who can guarantee high purity (e.g., ≥97%) and consistent quality. The ability to reliably source such building blocks from manufacturers in regions like China, known for their robust chemical production capabilities, is vital for the progress of pharmaceutical research and the eventual market availability of new medicines.

Procurement Considerations

For any scientist or procurement manager looking to incorporate 2-Bromo-5-fluorophenol into their workflow, understanding its sourcing landscape is important. Engaging with established chemical suppliers and manufacturers is key. These entities can provide detailed product specifications, safety data sheets (SDS), and competitive price quotes. Leveraging the CAS number (147460-41-1) is the most effective way to search for this specific compound. Ensuring a stable supply chain for such specialized building blocks is fundamental to the uninterrupted progress of research and production efforts.

In essence, 2-Bromo-5-fluorophenol embodies the utility of aryl fluorinated building blocks in modern chemistry. Its multifaceted reactivity makes it indispensable for creating intricate molecules, particularly in the vital field of pharmaceutical intermediates. As the demand for innovative pharmaceuticals continues to grow, so too will the importance of compounds like 2-Bromo-5-fluorophenol and the manufacturers who supply them.