For researchers and scientists engaged in chemical R&D, the availability of versatile and high-quality building blocks is paramount to exploring new frontiers in synthesis and material science. 2-Bromothiophene (CAS: 1003-09-4) stands out as a particularly valuable compound due to its unique structure and reactivity. This article provides an essential overview for R&D professionals, detailing its chemical properties, diverse applications, and guidance on how to effectively source this key intermediate.

The Chemical Identity of 2-Bromothiophene

2-Bromothiophene is an organobromine compound derived from thiophene, a sulfur-containing aromatic heterocycle. Its molecular formula is C4H3BrS, with a molecular weight of 163.04. It typically appears as a clear, colorless to pale yellow liquid, possessing a distinct odor. Key physical characteristics include a boiling point of approximately 149-151 °C and a density of around 1.684 g/mL at 25 °C. Its miscibility profile indicates it is immiscible with water but readily dissolves in common organic solvents like diethyl ether and acetone. The compound is also light-sensitive, necessitating storage in appropriate, sealed containers away from direct light to maintain its integrity.

The compound's CAS number, 1003-09-4, serves as a unique identifier, simplifying searches for suppliers and technical information. For R&D purposes, the purity of 2-Bromothiophene is a critical parameter, with high-purity grades (≥99%) often preferred to ensure the predictability and success of complex synthetic endeavors.

Versatile Applications in Research and Synthesis

While 2-Bromothiophene is widely recognized for its role as an intermediate in the synthesis of pharmaceuticals, such as the antiplatelet drug Clopidogrel, its utility extends broadly across various R&D disciplines:

  • Organic Synthesis: Its structure makes it an excellent substrate for a range of reactions, including Grignard reactions, palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Heck), and lithiation followed by electrophilic quench. These reactions allow for the introduction of diverse functional groups onto the thiophene ring.
  • Material Science: Thiophene derivatives are integral to the development of advanced materials, particularly in organic electronics. 2-Bromothiophene can be used as a monomer or building block for conjugated polymers and oligomers with conductive or semiconductive properties, relevant for organic thin-film transistors (OTFTs), organic photovoltaics (OPVs), and organic light-emitting diodes (OLEDs).
  • Medicinal Chemistry: Beyond established drugs, chemists use 2-Bromothiophene to synthesize novel chemical entities for drug discovery programs, exploring its potential in various therapeutic areas.
  • Catalysis Research: As a thiophene-based compound, it can be involved in research related to organometallic catalysts or ligands.

For R&D scientists, the ability to easily buy 2-bromothiophene in quantities suitable for laboratory scale experiments is essential. Accessing reliable manufacturers and suppliers who cater to the research community is key.

Strategic Sourcing for R&D

When sourcing 2-Bromothiophene for research and development, scientists should:

  • Prioritize Purity: Opt for grades with assay ≥99% to avoid interference in sensitive reactions.
  • Seek Reputable Suppliers: Look for manufacturers or distributors with a strong online presence and clear product information, including CAS numbers and specifications.
  • Request Samples: If available, ordering small sample quantities can be beneficial for initial testing and validation.
  • Compare Pricing and Availability: Even for R&D, understanding market prices and lead times is important for project planning.

In conclusion, 2-Bromothiophene is a chemical workhorse for the modern R&D laboratory. Its versatile reactivity and application in cutting-edge fields like material science and medicinal chemistry make it an invaluable intermediate. By understanding its properties and adopting a strategic approach to sourcing, R&D professionals can ensure they have a reliable supply of this essential compound to drive their innovative projects forward.