In the intricate world of organic synthesis, understanding the physical and chemical properties of key intermediates is fundamental for successful research and development. 2-Chloro-3-nitropyridin-4-ol, identified by CAS number 629655-23-8, is one such compound that offers significant utility. This article aims to highlight the critical properties of this light yellow crystalline powder, providing valuable insights for chemists and procurement specialists looking to buy this essential building block.

The chemical structure of 2-Chloro-3-nitropyridin-4-ol is characterized by a pyridine ring substituted with a chlorine atom at the 2-position, a nitro group at the 3-position, and a hydroxyl group at the 4-position. This unique arrangement imparts specific reactivity, making it an attractive starting material for a variety of synthetic transformations. For instance, the electron-withdrawing nature of the nitro group and the electronegativity of chlorine can influence the reactivity of the pyridine ring towards nucleophilic or electrophilic attack. Researchers often seek this compound to introduce these specific functionalities into larger, more complex molecules.

Key physical properties, such as its appearance as a light yellow crystalline powder, provide an initial visual indicator of quality. While specific applications dictate the exact requirements, an assay of ≥98.0% is a common benchmark for high-purity intermediates, ensuring reliability in synthesis. Understanding other reported physical data, like density (around 1.7 g/cm³) and boiling point (approximately 408.2 °C at 760 mmHg), can also be beneficial for process design and hazard assessment. However, it's crucial for buyers to consult the most up-to-date technical specifications provided by the manufacturer.

The utility of 2-Chloro-3-nitropyridin-4-ol as an intermediate in organic synthesis cannot be overstated. It serves as a crucial precursor in the preparation of various heterocyclic compounds, which are often found in pharmaceuticals and agrochemicals. For example, the nitro group can be reduced to an amine, creating a new point for derivatization or amide formation. The chlorine atom can be readily displaced by various nucleophiles in SNAr reactions, allowing for the introduction of diverse substituents onto the pyridine core. Procurement managers looking to buy this intermediate should prioritize suppliers who can consistently deliver material meeting these critical property specifications.

In conclusion, a thorough understanding of the properties of 2-Chloro-3-nitropyridin-4-ol is vital for its effective application in organic synthesis. By focusing on purity, chemical reactivity, and reliable sourcing from experienced manufacturers, R&D professionals can successfully integrate this valuable intermediate into their projects. If you are in the market to buy this chemical, consider its detailed properties and partner with suppliers who prioritize quality and technical support.