For chemists, R&D scientists, and material science professionals, a deep understanding of chemical properties is key to successful synthesis and application. 2-Chloro-4-Methylpyrimidine (CAS 13036-57-2) is a compound that presents a compelling profile of reactivity and utility. As a pyrimidine derivative, its structure and chemical behavior make it valuable across various scientific disciplines, from pharmaceutical research to advanced organic synthesis.

Key Chemical Properties and Specifications

2-Chloro-4-Methylpyrimidine, with the molecular formula C5H5ClN2 and a molecular weight of 128.56 g/mol, is characterized by a reactive chlorine atom at the 2-position of the pyrimidine ring and a methyl group at the 4-position. Its physical appearance is typically described as a white powder. Key specifications often include a melting point in the range of 35-47°C, as reported by various suppliers, and a boiling point of approximately 94°C/17mmhg. The predicted density is around 1.234±0.06 g/cm³. Its solubility in common organic solvents such as ether is also a critical property for handling in laboratory settings. The presence of the chlorine atom makes it susceptible to nucleophilic substitution reactions, a cornerstone of its synthetic utility. For procurement managers seeking this compound, understanding these specifications, alongside purity levels often exceeding 97%, is crucial for ensuring it meets the requirements of their specific chemical processes.

Diverse Applications in Research and Industry

The primary application for 2-Chloro-4-Methylpyrimidine is as a pharmaceutical intermediate, most notably in the synthesis of Dabrafenib Mesylate, a targeted therapy for certain cancers. Beyond this significant role, its reactive nature makes it a versatile reagent in general organic synthesis. Researchers can utilize it to build more complex heterocyclic compounds, explore novel chemical reactions, or develop new functional materials. Its presence in scientific research often extends to areas like agrochemical synthesis or the creation of specialty chemicals. For laboratories and manufacturers, purchasing this compound from reliable suppliers ensures access to a consistent and high-quality building block for a wide array of synthetic endeavors. When buying, inquire about its availability for research purposes and any specific application notes.

Sourcing and Quality Assurance

When looking to buy 2-Chloro-4-Methylpyrimidine (CAS 13036-57-2), it is important to partner with suppliers who can guarantee product quality and provide comprehensive documentation. Manufacturers in China, for example, often offer competitive pricing and have the capacity to meet bulk requirements. Checking for certifications and ensuring that each batch comes with a Certificate of Analysis (COA) detailing purity and other critical parameters is essential. For R&D scientists requiring specific purities or quantities, exploring custom synthesis services from reputable manufacturers can provide tailored solutions. Understanding the chemical properties and potential applications will guide procurement decisions, ensuring that 2-Chloro-4-Methylpyrimidine effectively serves its purpose in your research or production line.

In summary, 2-Chloro-4-Methylpyrimidine (CAS 13036-57-2) is a valuable chemical intermediate with well-defined properties and significant applications, particularly in pharmaceutical synthesis. By focusing on quality sourcing and understanding its chemical characteristics, researchers and procurement professionals can effectively leverage this compound for their scientific and industrial needs. If you intend to purchase, seek out expert suppliers who can provide detailed specifications and ensure product integrity.