The landscape of modern organic synthesis is continuously shaped by the development and availability of sophisticated chemical building blocks. Among these, heterocyclic compounds with strategically placed functional groups are particularly valuable. 2-Chloro-5-fluoro-4-iodopyridine, bearing the CAS number 884494-49-9, exemplifies such a versatile molecule. Its unique structural features make it a prime candidate for use in a multitude of chemical transformations, essential for R&D scientists and product developers across various industries, especially pharmaceuticals and agrochemicals. For those looking to buy this critical intermediate, understanding its chemical profile and sourcing reliably is paramount.

Chemical Profile and Synthesis Potential:

With a molecular formula of C5H2ClFIN and a molecular weight of 257.43, 2-Chloro-5-fluoro-4-iodopyridine presents a robust platform for synthetic chemists. Its physical state is typically solid, with a defined melting point range contributing to its handling ease in laboratory settings. The presence of three different halogen atoms on the pyridine ring—chlorine, fluorine, and iodine—provides differential reactivity. The iodine atom, being the most reactive halogen in many coupling reactions, allows for selective functionalization via palladium-catalyzed processes like Suzuki, Heck, and Sonogashira couplings. This enables the facile introduction of aryl, vinyl, or alkynyl groups, significantly expanding the molecular complexity that can be achieved. The fluorine atom often imparts desirable properties such as increased lipophilicity and metabolic stability to target molecules, while the chlorine atom can be utilized in nucleophilic aromatic substitution reactions or further cross-coupling transformations. This high degree of synthetic flexibility makes it an attractive compound to purchase for complex molecule synthesis.

Applications in Research and Development:

The primary utility of 2-Chloro-5-fluoro-4-iodopyridine lies in its role as an advanced intermediate. In the pharmaceutical sector, it is employed in the synthesis of novel drug candidates targeting various therapeutic areas. Its ability to participate in diverse coupling reactions allows for the rapid generation of compound libraries for screening. For agrochemical research, this pyridine derivative is instrumental in developing new generations of pesticides and herbicides that offer improved efficacy and reduced environmental impact. Procurement managers seeking to buy this compound are often involved in projects that require precise molecular architectures for targeted biological activity.

Sourcing from Reputable Manufacturers:

Identifying a dependable supplier for 2-Chloro-5-fluoro-4-iodopyridine is crucial for consistent research outcomes. Manufacturers based in China are often key sources due to their production capabilities and competitive pricing. When you intend to buy this chemical, look for suppliers that can guarantee high purity (typically 97% or above) and provide comprehensive analytical documentation like GC and NMR data. The stability of the compound under recommended storage conditions is also a key consideration. Partnering with a well-established chemical supplier ensures not only the quality of the product but also a streamlined procurement process, from quotation to delivery.

Conclusion:

2-Chloro-5-fluoro-4-iodopyridine is a testament to the power of functionalized heterocyclic building blocks in modern chemistry. Its broad synthetic applicability makes it an essential component for driving innovation in critical industries. By understanding its chemical properties and ensuring a reliable procurement process from trusted manufacturers, researchers and developers can effectively leverage this compound to achieve their synthetic goals.