For professionals working in the chemical and pharmaceutical industries, a thorough understanding of product specifications and handling procedures is crucial for safe and effective operations. 2-Cyano-5-nitropyridine (CAS 100367-55-3) is a versatile synthetic intermediate, and knowing its detailed technical profile ensures optimal utilization and safety.

Key Technical Specifications:

  • Chemical Name: 2-Cyano-5-nitropyridine
  • CAS Number: 100367-55-3
  • Molecular Formula: C6H3N3O2
  • Molecular Weight: 149.11 g/mol
  • Appearance: Typically described as a green solid. This physical characteristic is important for visual identification upon receipt.
  • Purity: Manufacturers commonly specify a purity of ≥99.0%. This high purity is critical for applications where minimal by-products are desired, such as in pharmaceutical synthesis.
  • Melting Point: Reported values often range around 43 °C, indicating its solid state at room temperature.
  • Solubility: It is generally soluble in common organic solvents like Ethyl Acetate and Methanol, which is important for reaction setup and purification processes.
  • Loss on Drying: Usually specified as ≤2.0%, indicating low moisture content.
  • Heavy Metals: Typically limited to ≤10 ppm, a critical parameter for pharmaceutical intermediates.
  • Water Content: Often specified as ≤1.0%.
  • Sulphated Ash: Usually ≤0.5% when determined on a 1.0 g sample.

Safety and Handling Precautions:

As with many fine chemicals, 2-Cyano-5-nitropyridine requires careful handling. According to GHS classifications, it may be classified as a skin irritant (Category 2), eye irritant (Category 2), and may cause respiratory irritation (Specific target organ toxicity – single exposure, Category 3). Therefore, it is essential to:

  • Wear Personal Protective Equipment (PPE): Always use appropriate gloves, eye protection (safety glasses or goggles), and protective clothing when handling the material.
  • Avoid Inhalation: Handle in a well-ventilated area or under a fume hood to prevent inhalation of dust or vapors.
  • Prevent Skin and Eye Contact: In case of contact, immediately wash affected areas with plenty of water.
  • Fire Safety: While specific flammability data might require consulting the SDS, general precautions for organic solids should be followed.

Storage Recommendations:

Proper storage ensures the stability and longevity of 2-Cyano-5-nitropyridine. Recommended storage conditions typically include:

  • Store in a cool, dry, and well-closed container.
  • Keep away from moisture, strong light, and excessive heat.
  • Storage under an inert atmosphere at room temperature is often advised for maintaining maximum purity and stability.
  • It is generally considered stable under recommended storage conditions, with a shelf life of up to two years when stored appropriately.

Procurement Information:

When you decide to buy 2-Cyano-5-nitropyridine, it is important to source from reputable manufacturers or suppliers. Companies in China offer this compound with high purity and competitive pricing. Always request a Certificate of Analysis (CoA) to verify the specifications of the received batch. Understanding these technical details empowers you to use this valuable synthetic intermediate effectively and safely in your research and production processes.