In the intricate world of chemical synthesis, the selection of appropriate building blocks can dictate the success of a project. 2-Fluoro-3-methylphenol (CAS: 77772-72-6) is a compound that has gained significant attention due to its versatile nature and utility in creating complex molecules. This article delves into the core chemical properties of this intermediate and highlights its critical applications, providing valuable insights for R&D scientists and formulation chemists.

Key Chemical and Physical Properties

Understanding the intrinsic properties of 2-Fluoro-3-methylphenol is essential for its effective utilization in synthesis. Supplied as a colorless transparent liquid, it boasts a high purity, typically exceeding 98.0%. This level of purity is crucial for predictable reaction outcomes and minimizing unwanted side products in sensitive synthesis pathways.

  • Molecular Formula and Weight: C7H7FO, with a molecular weight of 126.13 g/mol.
  • Boiling Point: Reported around 174.2 ± 20.0 °C at 760 mmHg, indicating its relative volatility and suitability for reactions requiring specific temperature controls.
  • Density: Approximately 1.164 ± 0.06 g/cm³, a useful parameter for volumetric calculations and handling.
  • Flash Point: Recorded at 67.4 ± 10.5 °C, providing important safety information for storage and laboratory handling.
  • Vapor Pressure: Around 0.9 ± 0.3 mmHg at 25°C, which is relevant for reactions conducted under vacuum or in closed systems.

The presence of a fluorine atom on the aromatic ring significantly influences the compound's reactivity and the properties of the derivatives it forms. This makes it a sought-after intermediate for chemists looking to introduce specific functionalities into their target molecules.

Synthesis Applications and Industry Impact

The primary utility of 2-Fluoro-3-methylphenol lies in its role as an intermediate for organic synthesis. Its structure allows for various chemical transformations, enabling its incorporation into diverse molecular architectures:

  • Pharmaceutical Intermediates: It is a critical building block for synthesizing active pharmaceutical ingredients (APIs). The introduction of fluorine can modify a drug’s lipophilicity, binding affinity, and metabolic profile, enhancing its therapeutic efficacy. Researchers looking to buy this intermediate can rely on its consistent quality from reputable manufacturers.
  • Agrochemical Intermediates: This compound is also valuable in the agrochemical sector, serving as a precursor for herbicides, insecticides, and fungicides. Its inclusion in active ingredients can improve their potency and spectrum of activity against pests and diseases. Sourcing from trusted suppliers in China ensures competitive pricing for large-scale production.
  • Functional Materials: Beyond life sciences, 2-Fluoro-3-methylphenol is used in the development of advanced materials. These can include specialty polymers, electronic chemicals, or performance additives where its specific chemical characteristics are beneficial.

For R&D scientists and product formulators, securing a reliable supply of high-purity 2-Fluoro-3-methylphenol from a reputable manufacturer is crucial. Companies looking for a consistent supplier in China can find competitive pricing and excellent quality. Understanding the detailed specifications and application potential will aid in making informed purchasing decisions.