As a pivotal component in modern chemical synthesis, 2-Fluoro-4-nitrotoluene (CAS: 1427-07-2) offers a unique combination of functional groups that unlock diverse applications. This article delves into its fundamental properties, common synthesis pathways, and its commercial significance, providing valuable insights for researchers and procurement professionals. Understanding these aspects is crucial for anyone looking to buy this intermediate from a reliable manufacturer.

Physical and Chemical Properties

2-Fluoro-4-nitrotoluene typically presents as a light yellow crystalline powder. Its molecular formula is C7H6FNO2, with a molecular weight of 155.13 g/mol. Key physical properties include a melting point range of 31-35°C and a boiling point of 65-68°C at 2 mm Hg. The compound is soluble in common organic solvents like ethanol and methanol but exhibits low solubility in water. Its stability requires proper storage, typically in a cool, dry, and well-ventilated place, keeping the container tightly closed.

Synthesis Methods

The synthesis of 2-Fluoro-4-nitrotoluene commonly involves the nitration of 2-fluorotoluene using a mixture of nitric and sulfuric acids. This electrophilic aromatic substitution reaction preferentially places the nitro group at the para position relative to the fluorine atom due to electronic directing effects. While this method is industrially established, ongoing research focuses on more sustainable and efficient routes, including catalytic nitration using solid acid catalysts. For bulk purchases, working with a manufacturer that has optimized these synthesis processes ensures consistent quality and yield.

Commercial Applications

The primary commercial value of 2-Fluoro-4-nitrotoluene lies in its role as a versatile intermediate:

  • Pharmaceutical Industry: It is a key building block in the synthesis of various Active Pharmaceutical Ingredients (APIs), including antiviral, antibacterial, and anticancer agents. Its structure can be modified to create complex drug molecules with specific therapeutic targets.
  • Agrochemical Industry: It serves as an essential precursor for the production of herbicides, insecticides, and fungicides, contributing to the development of effective crop protection solutions.
  • Electronics Industry: This compound is utilized in the synthesis of high-performance liquid crystal materials and organic semiconductors, critical for advancements in electronic displays and organic electronics.

When sourcing this chemical, consider manufacturers in China known for their expertise in fine chemical production. They can offer competitive pricing and reliable supply, ensuring you have the materials needed for your manufacturing and R&D endeavors. Always inquire about the specific grade and packaging suitable for your application. Securing a consistent supplier for 2-Fluoro-4-nitrotoluene is a strategic move for any company involved in advanced chemical manufacturing.