For R&D scientists and formulation chemists, identifying and sourcing the right chemical building blocks is the first step towards groundbreaking pharmaceutical innovations. 2-Fluoro-6-methylbenzoic acid (CAS 90259-27-1) has emerged as a cornerstone intermediate, particularly in the synthesis of cutting-edge Active Pharmaceutical Ingredients (APIs). Its unique fluorinated structure and reactive functional groups make it invaluable for creating complex molecular architectures.

The Chemical Significance of 2-Fluoro-6-methylbenzoic Acid

This compound, with the molecular formula C8H7FO2 and a molecular weight of 154.14, possesses a benzoic acid core substituted with both a fluorine atom and a methyl group at the ortho positions. This specific arrangement dictates its reactivity and suitability for various synthetic pathways. Its physical properties, typically appearing as an off-white to white crystalline powder with a melting point around 124-125°C, are consistent with high-purity organic compounds. The crucial aspect for synthesis chemists is its reliability in reactions, ensuring predictable outcomes and efficient yield.

Applications in Modern Drug Discovery

The primary utility of 2-Fluoro-6-methylbenzoic acid lies in its role as an intermediate for API synthesis. It plays a pivotal part in the production of therapeutic agents such as EGFR inhibitors, which are critical in oncology. Furthermore, it is a key building block for avacopan, a drug used to treat ANCA-associated vasculitis. Scientists looking to buy 2-fluoro-6-methylbenzoic acid for these or similar projects will find its consistent quality and specific functional groups immensely beneficial. Researchers often search for 'pharmaceutical intermediate price' or 'API synthesis building blocks' to identify cost-effective and high-quality materials.

Sourcing Strategies for R&D Scientists

When sourcing 2-Fluoro-6-methylbenzoic acid for your laboratory or R&D projects, consider focusing on suppliers who can provide detailed technical data and ensure high purity (≥99.0% by HPLC). Engaging with manufacturers directly, particularly those in regions known for robust chemical production like China, can offer advantages in terms of price and availability. Utilizing specific search terms like 'high purity 2-fluoro-6-methylbenzoic acid' or 'CAS 90259-27-1 for sale' will help you identify reliable sources. Understanding the synthesis routes and potential side reactions where this intermediate is employed will further enhance your ability to select the most appropriate supplier and material.

In essence, 2-Fluoro-6-methylbenzoic acid is more than just a chemical; it's an enabler of advanced pharmaceutical development. By focusing on quality, purity, and dependable sourcing, R&D scientists can confidently integrate this vital intermediate into their synthesis protocols, paving the way for the next generation of medicines.