For researchers and development scientists in the chemical and pharmaceutical industries, understanding the nuanced properties of key intermediates is fundamental to innovation. 2-Fluoroaniline, identified by its CAS number 348-54-9, is a compound that consistently proves its worth as a versatile building block. This article explores its chemical characteristics and highlights its critical applications, providing insights for those looking to buy this essential reagent for their R&D endeavors.

At its core, 2-Fluoroaniline (C6H6FN) is an aromatic amine featuring a fluorine atom substituted at the ortho position relative to the amino group. This structural detail is significant. The electronegativity of fluorine influences the electron distribution within the benzene ring and affects the reactivity of the amino group. This often leads to enhanced stability or altered reaction pathways compared to its non-fluorinated counterpart, aniline. The compound's molecular weight is approximately 111.12 g/mol. In its pure form, it presents as a clear, colorless to slightly brownish liquid, with a boiling point around 182-183 °C. Its solubility in water is limited, but it readily dissolves in common organic solvents like ethanol and ether, making it amenable to a wide range of reaction conditions and purification techniques.

The R&D applications of 2-Fluoroaniline are extensive and growing. In pharmaceutical research, it serves as a crucial starting material or intermediate for synthesizing complex drug molecules. The introduction of fluorine can significantly impact a drug candidate's pharmacokinetic properties, such as membrane permeability, metabolic stability, and receptor binding affinity. This makes 2-Fluoroaniline a valuable component in the design of novel therapeutic agents. Beyond pharmaceuticals, it is employed in the synthesis of agrochemicals, where its structural features can contribute to pesticide efficacy and environmental persistence profiles. Furthermore, it acts as a reagent in the development of advanced materials, including polymers and dyes, where the fluorine moiety can impart desired characteristics like thermal stability or specific optical properties.

Scientists often need to purchase 2-Fluoroaniline with high purity to ensure the reliability and reproducibility of their experiments. Impurities can lead to side reactions, lower yields, and inaccurate results, which are particularly detrimental in the early stages of drug discovery or material science research. Therefore, when sourcing 2-Fluoroaniline (CAS 348-54-9), it is vital to partner with suppliers who can guarantee stringent quality control and provide detailed analytical data, such as Gas Chromatography (GC) or High-Performance Liquid Chromatography (HPLC) reports. Manufacturers in China are increasingly recognized for their ability to deliver these high-purity fine chemicals at competitive prices, making them an attractive option for global R&D teams.

For research institutions and companies looking to buy 2-Fluoroaniline, understanding its classification is also important. It is typically categorized as a fine chemical or a pharmaceutical intermediate. Safety considerations are paramount; it's classified as harmful and toxic, requiring appropriate handling procedures, personal protective equipment (PPE), and adherence to safety data sheets (SDS). When you need to buy this compound, consider consulting with experienced chemical suppliers who can provide not only the material but also relevant safety and handling information, ensuring your research is both productive and safe.

In summary, 2-Fluoroaniline (CAS 348-54-9) is an indispensable tool for R&D scientists. Its unique chemical properties, driven by the ortho-fluorine substitution, unlock a vast array of possibilities in drug discovery, agrochemical development, and material science. By sourcing high-purity material from reputable manufacturers and suppliers, researchers can confidently advance their projects. If you are seeking to purchase this key intermediate, explore the offerings from trusted global chemical providers.