The journey from a promising molecule to a marketable drug is complex and relies heavily on the availability of precisely engineered chemical building blocks. 2-Iodo-6-(trifluoromethyl)pyridine, identified by CAS number 100366-74-3, stands out as a pivotal intermediate in this process. Its unique structure, featuring a pyridine core with both an iodine atom and a trifluoromethyl group, makes it exceptionally valuable for organic chemists in drug discovery and development. As a prominent manufacturer and supplier from China, we are dedicated to ensuring this essential compound is accessible to the global pharmaceutical industry.

Understanding the Chemical Profile

2-Iodo-6-(trifluoromethyl)pyridine is typically supplied as a white powder, with a guaranteed purity of 99% minimum. This high level of purity is crucial, especially in pharmaceutical applications where even trace impurities can affect reaction outcomes or the safety profile of the final drug. The iodine atom serves as an excellent leaving group or reaction handle for various coupling reactions, while the trifluoromethyl group is often incorporated into drug candidates to modulate properties like lipophilicity, metabolic stability, and binding affinity. Its molecular formula is C6H3F3IN.

Applications in Pharmaceutical Synthesis

The primary application of 2-Iodo-6-(trifluoromethyl)pyridine lies in its role as a pharmaceutical intermediate. It is a versatile reagent for constructing more complex molecular architectures. Common synthetic pathways involve:

  • Cross-Coupling Reactions: Facilitating the formation of carbon-carbon or carbon-heteroatom bonds through catalyzed reactions like Suzuki, Stille, Heck, and Sonogashira couplings. This allows for the attachment of diverse chemical fragments to the pyridine ring.
  • Heterocyclic Chemistry: Serving as a precursor for the synthesis of various fused or substituted heterocyclic systems, which are common scaffolds in many drug classes.
  • Medicinal Chemistry Research: Enabling the exploration of structure-activity relationships (SAR) by allowing chemists to systematically modify molecular structures and evaluate their biological activity.

Sourcing Strategies for Procurement Managers

For procurement managers, sourcing 2-Iodo-6-(trifluoromethyl)pyridine efficiently involves a strategic approach. Key considerations include:

  • Supplier Vetting: Identifying manufacturers with established quality management systems (e.g., ISO certification) and a proven history in producing pharmaceutical intermediates.
  • Price Inquiry and Negotiation: Obtaining multiple quotes from reputable suppliers to secure the best possible price without compromising quality. When you buy in bulk, economies of scale can lead to significant cost savings.
  • Lead Times and Logistics: Understanding the typical lead times for manufacturing and shipping, especially for international orders, is vital for production planning. Our 25kg/drum packaging is designed for efficient logistics and storage.
  • Technical Support: Partnering with a supplier that can offer technical data sheets (TDS) and material safety data sheets (MSDS) adds value and ensures proper handling and application.

As a leading chemical supplier in China, we are committed to providing high-quality 2-Iodo-6-(trifluoromethyl)pyridine to support your pharmaceutical endeavors. We invite you to contact us to discuss your specific requirements, obtain a price quote, and explore how our reliable supply can benefit your research and development pipeline.