Medicinal chemistry is the engine that drives pharmaceutical innovation, constantly seeking to design and synthesize molecules with improved therapeutic efficacy and safety profiles. Within this dynamic field, specific chemical building blocks play a pivotal role. 3-Amino-3-(4-trifluoromethylphenyl)propionic acid is one such compound, offering unique structural advantages that are highly sought after by researchers. As a dedicated supplier of specialty chemicals, we highlight why this particular amino acid derivative is essential for drug discovery and development efforts, and what to look for when you decide to buy.

The Significance of the Trifluoromethylphenyl Moiety
3-Amino-3-(4-trifluoromethylphenyl)propionic acid, with CAS number 180263-44-9, is a non-proteinogenic amino acid derivative that incorporates a trifluoromethyl group attached to a phenyl ring. This feature is highly valued in medicinal chemistry for several reasons. The trifluoromethyl group is known for its strong electron-withdrawing nature and its ability to increase lipophilicity. These properties can significantly influence a drug candidate's pharmacokinetic properties, such as absorption, distribution, metabolism, and excretion (ADME). Enhanced lipophilicity can lead to better penetration of biological membranes, including the blood-brain barrier, making it particularly interesting for developing CNS-acting drugs. Furthermore, the trifluoromethyl group can increase metabolic stability by blocking potential sites of oxidation.

Sourcing Strategy: Purity and Reliability from a Manufacturer
For medicinal chemists and procurement managers, sourcing high-quality 3-Amino-3-(4-trifluoromethylphenyl)propionic acid requires a focus on purity and a reliable supply chain. Our company, as a leading manufacturer and supplier, ensures that our product consistently meets rigorous quality standards, with a purity of ≥97% (HPLC). This guarantees that researchers can depend on the compound for reproducible experimental results and successful synthesis of complex molecules. We understand the importance of cost-effectiveness, especially in early-stage research, and thus offer competitive pricing for this valuable intermediate. When considering where to buy, a supplier that can provide certificates of analysis and offer technical support adds significant value to your procurement process.

Applications Driving Innovation
The application of 3-Amino-3-(4-trifluoromethylphenyl)propionic acid in medicinal chemistry is broad and impactful:

  • Drug Design: Used as a scaffold to create novel molecules targeting various disease pathways, leveraging its favorable pharmacokinetic properties.
  • Structure-Activity Relationship (SAR) Studies: Investigating how structural modifications, like the trifluoromethyl group, affect biological activity.
  • Peptide Modification: Incorporating into peptides to enhance their drug-like properties and therapeutic potential.
  • Asymmetric Synthesis: Serving as a chiral building block in the synthesis of enantiomerically pure compounds.

Your Trusted Partner in Chemical Sourcing
As you advance your medicinal chemistry projects, having a dependable supplier for critical intermediates like 3-Amino-3-(4-trifluoromethylphenyl)propionic acid is crucial. We are committed to supporting the pharmaceutical industry by providing high-quality, reliably sourced chemical compounds. We invite you to contact us to discuss your specific project needs, request a quotation, and learn more about how we can be your preferred manufacturer and supplier for this vital chemical building block. Empower your research with quality materials and expert support.