In the dynamic world of chemical research and development, versatile intermediates are the bedrock upon which innovation is built. 3-Aminophenylacetylene, identified by CAS number 54060-30-9, stands out as such a compound, offering a unique combination of functional groups that unlock a wide array of synthetic possibilities. For R&D scientists, understanding its properties and applications is key to leveraging its full potential.

Chemical Profile and Reactivity

3-Aminophenylacetylene is characterized by its benzene ring substituted with an amino (-NH₂) group and an ethynyl (-C≡CH) group. This dual functionality is the source of its versatility:

  • Amino Group: Acts as a nucleophile, readily participating in acylation, alkylation, and condensation reactions. It also offers potential for hydrogen bonding and salt formation.
  • Alkyne Group: The terminal alkyne is highly reactive in various transformations, including click chemistry (e.g., Copper-catalyzed Azide-Alkyne Cycloaddition), Sonogashira cross-coupling, and other addition reactions.

This reactivity profile makes 3-Aminophenylacetylene an invaluable building block for synthesizing complex organic molecules.

Diverse Applications Across Industries

The utility of 3-Aminophenylacetylene spans several critical sectors:

  • Pharmaceuticals: It is a key intermediate in the synthesis of targeted anticancer drugs like Erlotinib and Icotinib, where its structure is integral to the drug's mechanism of action.
  • Materials Science: When reacted with monomers like maleic anhydride, it forms high-performance polyimides. These resins exhibit excellent thermal stability, high mechanical strength, and resistance to wear, making them suitable for aerospace, aviation, and military applications.
  • Organic Synthesis: As a versatile reagent, it's used in creating new chemical entities, functionalizing surfaces, and developing novel polymers and dyes.
  • Biotechnology: Derivatives can serve as fluorescent markers in immunoassay techniques.

Sourcing for Research and Development

For R&D scientists, securing a reliable supply of high-purity 3-Aminophenylacetylene (typically ≥99%) is essential for reproducible and successful experiments. When considering where to buy, it's beneficial to look for suppliers that offer detailed product information, including Certificates of Analysis and Safety Data Sheets. Many manufacturers in China offer this intermediate at competitive prices, providing global access. As a leading manufacturer, we are dedicated to providing R&D professionals with the high-quality intermediates they need to drive chemical innovation. Enquire with us for your specific requirements and to secure a dependable supply.

3-Aminophenylacetylene is more than just a chemical; it's an enabler of scientific progress. Its strategic use in pharmaceuticals, advanced materials, and general organic synthesis highlights its importance in the modern chemical landscape.