3-Bromo-2-fluorophenol (CAS: 156682-53-0) is a highly functionalized aromatic compound that serves as a valuable intermediate in the chemical industry. Its unique combination of a hydroxyl group, a bromine atom, and a fluorine atom imparts specific chemical reactivities, making it a sought-after building block for pharmaceuticals, agrochemicals, and fine chemicals. Understanding its properties, synthesis routes, and safe handling practices is essential for any industrial user. As a leading manufacturer and supplier, we are committed to providing comprehensive information to support your procurement and application needs.

Physically, 3-Bromo-2-fluorophenol typically presents as a white solid, with a reported boiling point of approximately 207.4°C. Its molecular formula is C₆H₄BrFO, and it has a molecular weight of around 191 g/mol. The presence of the hydroxyl group makes it a weak acid, with an estimated pKa of around 2.88. The electron-withdrawing effects of both bromine and fluorine atoms influence the electron density of the aromatic ring, playing a significant role in its reactivity towards various chemical transformations.

Synthetically, 3-Bromo-2-fluorophenol can be accessed through several pathways. Common methods involve electrophilic aromatic substitution reactions, often requiring careful control of reaction conditions to achieve the desired regioselectivity. Strategies may include the directed bromination of fluorophenols or the fluorination of bromophenols, with challenges often arising from the directing effects of the existing substituents. For large-scale industrial synthesis, efficient and cost-effective routes are paramount, and manufacturers often optimize multi-step processes starting from more readily available precursors. When you buy this compound, understanding its synthesis is key to appreciating its quality.

Safe handling and storage are critical for any chemical intermediate. 3-Bromo-2-fluorophenol should be stored in a cool, dry, well-ventilated area, away from direct sunlight and sources of ignition. Personal protective equipment, including gloves, eye protection, and respiratory protection, should be used when handling the compound to avoid skin irritation, eye irritation, and respiratory tract irritation. For procurement managers and chemists, consulting the Material Safety Data Sheet (MSDS) provided by the supplier is the best practice for detailed safety information. As a trusted manufacturer, we ensure that our products are accompanied by comprehensive data and support to facilitate safe and effective industrial use.