The pharmaceutical industry constantly seeks novel compounds and efficient synthesis pathways to develop life-saving and life-enhancing drugs. Central to this endeavor is the availability of high-quality chemical intermediates. 3-Bromo-9H-fluoren-9-one, identified by CAS number 2041-19-2, is one such critical compound, playing a significant role in pharmaceutical research and development (R&D).

The Significance of 3-Bromo-9H-fluoren-9-one in Pharma R&D

3-Bromo-9H-fluoren-9-one is a functionalized fluorene derivative with a chemical formula of C13H7BrO and a molecular weight of 259.10 g/mol. Its structure, featuring a reactive bromine atom and a carbonyl group on the fluorene scaffold, makes it an excellent starting material for a multitude of synthetic transformations. It is typically supplied as a light yellow powder with a purity level of 97% or higher, ensuring its suitability for sensitive R&D applications.

In pharmaceutical R&D, this intermediate is valuable for several reasons:

  • Drug Discovery: It serves as a versatile building block for synthesizing complex molecular structures that are candidates for new drug therapies. Its reactive sites allow for diverse derivatization.
  • Process Chemistry: For developing scalable and efficient synthesis routes for potential drug candidates, a reliable supply of high-purity intermediates like 3-Bromo-9H-fluoren-9-one is essential.
  • Structure-Activity Relationship (SAR) Studies: Researchers often need to synthesize a series of related compounds to understand how structural modifications affect biological activity. 3-Bromo-9H-fluoren-9-one facilitates the creation of such analogues.

Sourcing Strategies for Pharmaceutical Companies

Pharmaceutical companies looking to buy 3-Bromo-9H-fluoren-9-one must prioritize quality and consistency. Working with reputable manufacturers and suppliers, particularly those with expertise in pharmaceutical intermediates, is key.

When sourcing from international markets, such as China, it's advisable to:

  • Verify Manufacturer Credentials: Ensure the manufacturer has experience and certifications relevant to pharmaceutical intermediate production.
  • Obtain Detailed Specifications: Confirm the purity, physical form, and CAS number (2041-19-2) match your requirements. Certificates of Analysis (CoA) are vital.
  • Compare Pricing and Lead Times: Engage with multiple suppliers to secure competitive pricing and understand delivery timelines, crucial for R&D project management.
  • Request Samples: A small sample order can validate the supplier's quality and consistency before placing a larger bulk order.

Conclusion

3-Bromo-9H-fluoren-9-one (CAS 2041-19-2) is an indispensable tool in the arsenal of pharmaceutical R&D. Its strategic importance in drug discovery and process development necessitates careful sourcing. By partnering with reliable suppliers and manufacturers who can provide high-purity material at a competitive price, pharmaceutical companies can effectively advance their research pipelines and accelerate the development of new medicines.