Advanced organic synthesis is the cornerstone of innovation in pharmaceuticals, agrochemicals, and materials science. Chemists rely on versatile building blocks that offer predictable reactivity and facilitate the construction of complex molecular structures. 3-Chloro-2-fluoropyridine, a halogenated pyridine derivative, has proven to be an indispensable tool in this field.

With the CAS number 1480-64-4, 3-Chloro-2-fluoropyridine is characterized by its pyridine ring substituted with both a chlorine and a fluorine atom. This dual halogenation provides multiple avenues for synthetic manipulation. The electronegativity of fluorine influences the electron density of the ring, while the chlorine atom serves as an excellent leaving group in various substitution and cross-coupling reactions. This makes it a highly adaptable starting material for creating a wide array of functionalized compounds.

In advanced organic synthesis, chemists frequently employ 3-Chloro-2-fluoropyridine in reactions such as palladium-catalyzed cross-couplings. For instance, it can readily participate in Suzuki-Miyaura coupling with boronic acids, Sonogashira coupling with terminal alkynes, and Buchwald-Hartwig amination with amines. These reactions allow for the precise formation of new carbon-carbon and carbon-nitrogen bonds, essential for assembling complex target molecules. The selective reactivity of the halogen atoms can often be controlled by judicious choice of reaction conditions and catalysts.

The demand for 3-Chloro-2-fluoropyridine is driven by its utility in synthesizing compounds with desirable biological activities or material properties. Researchers looking to buy 3-Chloro-2-fluoropyridine for their labs often seek suppliers who can ensure high purity (≥98.0%) and consistent quality. Sourcing from a reliable manufacturer, particularly one in China known for its expertise in fine chemical production, can provide access to competitive pricing and stable supply. Inquiring about the 3-Chloro-2-fluoropyridine price and availability is a key step for any synthesis chemist.

Ultimately, 3-Chloro-2-fluoropyridine empowers chemists to design and synthesize novel molecules with greater efficiency and control. Its strategic role in advanced organic synthesis underscores its importance as a fundamental chemical intermediate, enabling breakthroughs in various scientific disciplines.