In the intricate world of pharmaceutical synthesis, the quality and availability of key intermediates are non-negotiable. For those involved in the production of advanced targeted therapies, 3-Ethynylimidazo[1,2-b]pyridazine (CAS: 943320-61-4) stands out as an indispensable compound. This article delves into the specifics of this pharmaceutical intermediate, its crucial role in synthesizing the anti-cancer drug Ponatinib, and practical advice for procurement managers looking to buy from reliable manufacturers.

The Role of 3-Ethynylimidazo[1,2-b]pyridazine in Ponatinib Synthesis

Ponatinib is a potent multi-targeted tyrosine kinase inhibitor that has proven effective in treating patients with CML and Ph+ ALL, especially those who are resistant to other treatments. The synthesis of such a complex molecule requires highly specific and pure chemical precursors. 3-Ethynylimidazo[1,2-b]pyridazine serves as a foundational building block, contributing the characteristic imidazo[1,2-b]pyridazine core and an ethynyl functional group essential for Ponatinib's therapeutic activity. Researchers and process chemists rely on this intermediate to construct the final drug molecule efficiently and with high yield.

Key Chemical Properties and Specifications

For professionals in the pharmaceutical industry, understanding the precise specifications of intermediates is critical. 3-Ethynylimidazo[1,2-b]pyridazine is typically supplied as a yellow powder, with a guaranteed minimum assay of 96.0% or higher. Its chemical formula is C8H5N3, and its molecular weight is approximately 143.15 g/mol. These parameters are vital for ensuring accurate stoichiometry, predicting reaction outcomes, and maintaining the overall quality of the final API. When you buy 3-ethynylimidazo[1,2-b]pyridazine, always confirm these details from the supplier's Certificate of Analysis.

Procurement: Finding Reliable Manufacturers and Suppliers

The global supply chain for pharmaceutical intermediates is robust, with China being a dominant player in manufacturing and export. Identifying a trustworthy 3-ethynylimidazo[1,2-b]pyridazine supplier in China requires due diligence. Look for manufacturers with a proven track record in producing fine chemicals and pharmaceutical intermediates, adhering to strict quality control protocols. Websites listing chemical suppliers often provide details on purity, packaging, and the ability to supply in various quantities, from grams for research to kilograms or tons for commercial production.

When you are ready to purchase 3-ethynylimidazo[1,2-b]pyridazine, engage with suppliers who offer:

  • Competitive pricing: The Ponatinib intermediate price is a significant factor in overall API production costs.
  • Consistent quality: Ensuring a high assay (e.g., ≥98%) is paramount for reproducible synthesis.
  • Reliable delivery: Stable supply chains are critical for uninterrupted manufacturing schedules.
  • Technical support: Some suppliers can offer insights or data relevant to the intermediate's use.

Navigating the Buying Process

To initiate a purchase, send a detailed inquiry to your chosen 3-ethynylimidazo[1,2-b]pyridazine manufacturer. Specify your requirements, including quantity and any specific quality parameters. You will typically receive a quotation detailing the pharmaceutical intermediate price, lead times, and shipping options. Building a strong relationship with a reliable supplier is key to long-term success in API manufacturing.

In summary, 3-Ethynylimidazo[1,2-b]pyridazine is more than just a chemical compound; it is an enabler of advanced cancer therapies. By understanding its chemical nature and procurement channels, researchers and manufacturers can ensure they are well-equipped to source this vital intermediate, contributing to the development of groundbreaking treatments.