For chemists and researchers involved in organic synthesis, a deep understanding of the synthesis routes and chemical properties of key intermediates is fundamental. 3-Fluoro-4-nitroanisole (CAS 446-38-8) is one such compound, valued for its role in pharmaceuticals and material science. This article provides an overview of its synthesis and characteristic properties, offering essential knowledge for those looking to utilize this compound in their R&D efforts. If you are seeking to buy this intermediate, understanding these aspects can guide your selection of a reliable supplier.

Chemical Profile of 3-Fluoro-4-nitroanisole

3-Fluoro-4-nitroanisole, with the chemical formula C7H6FNO3 and molecular weight of 171.13 g/mol, is characterized by its off-white crystalline solid appearance. Its IUPAC name is 2-fluoro-4-methoxy-1-nitrobenzene. The compound's structure, featuring a fluorine atom at the 3-position and a nitro group at the 4-position of the anisole ring, imparts specific electronic and steric properties that are highly desirable in synthetic chemistry. As a key organic intermediate, its purity is often critical, with suppliers typically offering 98% or higher purity levels.

Common Synthesis Pathways

Several synthesis routes have been documented for 3-Fluoro-4-nitroanisole, reflecting its importance in chemical manufacturing. One common method involves starting materials such as 3-Fluoro-4-nitrophenol. Through a methylation process, often using agents like iodomethane in the presence of a base such as 1,8-diazabicyclo[5,4,0]undec-7-ene (DBU) in solvents like acetone, the methoxy group is introduced to yield the target compound. Other reported synthesis pathways may involve different precursors and reaction conditions, aiming for improved yields and purities. Understanding these routes is important for manufacturers in optimizing production and for researchers assessing synthesis efficiency.

Key Chemical Properties and Applications

The chemical properties of 3-Fluoro-4-nitroanisole make it a versatile building block. The presence of the fluorine atom can enhance the lipophilicity and metabolic stability of derived molecules, a crucial aspect in pharmaceutical development. The nitro group is a readily transformable functional group, often reduced to an amine, which can then participate in a wide array of further reactions, such as amide bond formation or as a nucleophile. This versatility makes it invaluable for creating complex molecular architectures. Researchers often seek this intermediate to develop new drugs, advanced materials, and other specialty chemicals. When you purchase this compound, ensuring you obtain it from a reputable supplier guarantees the quality necessary for these demanding applications.

Sourcing 3-Fluoro-4-nitroanisole for R&D

For those looking to utilize 3-Fluoro-4-nitroanisole in their research, it is important to partner with reliable manufacturers and suppliers. Companies specializing in fine chemicals often provide detailed technical data sheets, including melting points, solubility, and reactivity profiles. Access to this information, combined with competitive prices, supports efficient laboratory work and commercial scale-up. If you require this intermediate, consider contacting verified providers who can offer both the product and the necessary technical support.

Conclusion

3-Fluoro-4-nitroanisole (CAS 446-38-8) is a compound with well-defined synthesis pathways and valuable chemical properties that underpin its widespread use in drug discovery and material science. For researchers and procurement managers, understanding these facets is key to successful sourcing. By partnering with trusted manufacturers and suppliers, you can ensure access to high-quality intermediates at competitive prices, facilitating groundbreaking advancements.