In the intricate world of organic chemistry, specific building blocks are essential for constructing complex molecules. 3-Phenyltoluene, identified by its CAS number 643-93-6, is one such compound. Valued for its biphenyl structure and methyl substitution, it serves as a critical intermediate in numerous synthetic pathways. This article delves into the physicochemical properties of 3-Phenyltoluene and highlights its diverse applications, particularly for researchers and chemists involved in custom synthesis and fine chemical production.

Chemical Profile of 3-Phenyltoluene

3-Phenyltoluene, also known as 3-methylbiphenyl or m-phenyltoluene, possesses the molecular formula C₁₃H₁₂ and a molecular weight of 168.23 g/mol. Typically supplied as an off-white to white powder, it has a low melting point of 4-5°C, suggesting it can also exist as a liquid at room temperature. With a boiling point of around 272.7°C at atmospheric pressure, it exhibits moderate volatility. Its chemical structure features two phenyl rings connected by a single bond, with a methyl group attached at the meta position on one of the rings. This arrangement imparts specific reactivity and stability, making it a sought-after intermediate.

Key Applications in Organic Synthesis

The utility of 3-Phenyltoluene spans several domains within chemistry:

  • Pharmaceutical Intermediates: This is perhaps the most significant application. 3-Phenyltoluene serves as a precursor for synthesizing various APIs. Its biphenyl core is a common structural motif in many pharmaceuticals, contributing to their pharmacological activity. Researchers often look to buy this compound for developing new drug candidates.
  • Agrochemicals: Similar to pharmaceuticals, the structural features of 3-Phenyltoluene make it a valuable intermediate in the synthesis of certain agrochemical compounds, such as herbicides or pesticides.
  • Material Science: Derivatives of biphenyl, including methylated versions like 3-Phenyltoluene, have found applications in material science, particularly in the development of liquid crystals and organic light-emitting diodes (OLEDs) due to their thermal stability and optical properties.
  • Research and Development: As a versatile organic building block, it is widely employed in academic and industrial R&D for exploring new chemical reactions, catalysts, and the synthesis of novel compounds with unique functionalities. Chemists often seek suppliers offering high-purity grades for experimental work.

Synthesis and Sourcing Considerations

The synthesis of 3-Phenyltoluene often involves cross-coupling reactions, such as the Suzuki-Miyaura coupling, between appropriate aryl halides and arylboronic acids. For instance, coupling 3-iodotoluene with phenylboronic acid, or vice versa, under palladium catalysis can yield the desired product. Ensuring high purity is crucial, and analytical techniques like GC-MS and NMR are essential for characterization. When purchasing, it is vital to select a reliable manufacturer or supplier that guarantees consistent purity (typically 97% min) and offers competitive pricing, especially for bulk orders. Many suppliers in China specialize in these intermediates and can provide Certificates of Analysis (CoA) upon request.

Expert Support for Your Chemical Needs

As a dedicated supplier, we understand the critical role of high-quality intermediates like 3-Phenyltoluene. We are committed to providing researchers and manufacturers with reliable access to this compound, backed by stringent quality control and responsive customer service. Whether you are initiating a new drug discovery project or scaling up production, we are equipped to meet your requirements. Contact us today to inquire about pricing, availability, and to request a sample of our 3-Phenyltoluene.