In the intricate world of pharmaceutical manufacturing, specific chemical intermediates play pivotal roles in the creation of life-saving medications. One such compound is 4-(2-Aminoethyl)benzenesulfonamide (CAS: 35303-76-5), a molecule indispensable for the synthesis of Glipizide, a widely prescribed oral hypoglycemic agent used in the management of type 2 diabetes. Understanding the chemical characteristics and critical applications of this intermediate is essential for procurement managers and R&D scientists aiming to optimize their API production.

Chemical Profile of 4-(2-Aminoethyl)benzenesulfonamide

With the molecular formula C8H12N2O2S and a molecular weight of approximately 200.26 g/mol, 4-(2-Aminoethyl)benzenesulfonamide presents as a white to off-white crystalline powder. Its structure features an ethylamine group attached to a benzenesulfonamide core. This specific arrangement of functional groups makes it highly reactive and suitable for the complex synthetic pathways required for pharmaceutical production. Key physicochemical properties, such as its melting point (typically 146-153°C) and solubility, are well-defined, aiding in its handling and processing. The compound's stability under recommended storage conditions further enhances its utility as a reliable raw material.

The Indispensable Role in Glipizide Synthesis

The primary application of 4-(2-Aminoethyl)benzenesulfonamide lies in its function as a precursor or key intermediate in the synthesis of Glipizide. Glipizide, a second-generation sulfonylurea, works by stimulating the pancreas to release more insulin and by increasing the sensitivity of peripheral tissues to insulin, thereby lowering blood glucose levels. The successful construction of the Glipizide molecule relies heavily on the purity and structural integrity of intermediates like AEBS. Manufacturers producing Glipizide API must source this intermediate from reliable suppliers to ensure the final drug product is safe, effective, and compliant with all regulatory requirements. The availability of this intermediate at a reasonable price from qualified manufacturers is crucial for widespread access to diabetes treatment.

Quality Specifications and Manufacturing Considerations

For pharmaceutical applications, the quality of 4-(2-Aminoethyl)benzenesulfonamide is paramount. Manufacturers typically guarantee a high purity level, often exceeding 98.5% as determined by High-Performance Liquid Chromatography (HPLC). Other critical quality parameters include low loss on drying (typically ≤0.5%), low residue on ignition (≤0.12%), and controlled levels of related substances and impurities. Suppliers also provide detailed technical data sheets and batch-specific Certificates of Analysis (CoA) to confirm these specifications. When considering a purchase, it's vital to engage with suppliers who can provide robust documentation and adhere to cGMP-compliant practices. If you are looking to buy this intermediate, seek out manufacturers who offer batch-specific CoAs to ensure quality.

Beyond Glipizide: Other Applications

While its primary use is in Glipizide synthesis, 4-(2-Aminoethyl)benzenesulfonamide also finds applications in broader chemical synthesis. It can serve as a building block for other specialty sulfonamide compounds or as a reagent in organic chemistry research. Its amine and sulfonamide functionalities offer versatile reaction sites for developing novel molecular structures. Researchers may also utilize it in studies related to metabolic disorders or as a reference standard in analytical chemistry. For those in chemical research, acquiring this compound from a dependable supplier in China can be a cost-effective strategy.

In summary, 4-(2-Aminoethyl)benzenesulfonamide is a chemical intermediate of significant importance to the pharmaceutical industry, particularly for the production of antidiabetic drugs like Glipizide. Its specific chemical properties, high purity requirements, and role in therapeutic drug synthesis underscore the need for careful sourcing from reputable manufacturers. By prioritizing quality and engaging with knowledgeable suppliers, companies can secure this essential component for their API manufacturing needs.