In the dynamic field of pharmaceutical development, the availability of high-purity chemical intermediates is fundamental to successful drug discovery and manufacturing. 4-(2-Hydroxyethyl)benzaldehyde (CAS 163164-47-4) stands out as a pivotal building block, prized for its dual functionality that enables the synthesis of a diverse range of bioactive molecules. As a dedicated manufacturer and supplier of specialty chemicals, we recognize the critical importance of this compound for the pharmaceutical industry. We aim to provide our B2B partners with essential information on how this intermediate drives innovation and where to source it reliably.

The Dual Power of 4-(2-Hydroxyethyl)benzaldehyde in Drug Design

The molecular structure of 4-(2-Hydroxyethyl)benzaldehyde, featuring both a reactive aldehyde group and a hydrophilic hydroxyethyl (B10761427) moiety, makes it exceptionally versatile. This bifunctionality allows chemists to selectively modify either end of the molecule or utilize both to construct complex scaffolds required for targeted drug action. For pharmaceutical procurement specialists and R&D scientists, sourcing this intermediate is often a critical step in their synthesis pathways.

Its primary utility lies in its role as a precursor for several important classes of therapeutic agents:

  • Thromboxane Receptor Antagonists and Synthase Inhibitors: This is a primary application where 4-(2-Hydroxyethyl)benzaldehyde serves as a key intermediate. Thromboxanes are potent mediators of platelet aggregation and vasoconstriction, implicated in cardiovascular diseases. Derivatives synthesized from this compound are designed to block these effects, contributing to the development of novel antithrombotic and cardiovascular drugs.
  • Anti-inflammatory Agents: Research indicates that derivatives of this benzaldehyde can exhibit anti-inflammatory properties by modulating pathways involving enzymes like lipoxygenase (LOX). This potential makes it valuable in the search for new treatments for chronic inflammatory conditions.
  • Quinolone Derivatives: While not a direct precursor in all standard quinolone syntheses, the structural motif of substituted benzaldehydes is frequently employed to introduce diversity into quinolone-based antibacterial agents and other pharmaceuticals.

The ability to reliably buy high-purity 4-(2-hydroxyethyl)benzaldehyde is essential for ensuring the quality and efficacy of the final drug products. Therefore, understanding the specifications and sourcing options from reputable suppliers is crucial.

Ensuring Quality and Supply Chain Reliability

For pharmaceutical companies, consistency in chemical quality is non-negotiable. Impurities in intermediates can lead to off-target effects, reduced drug potency, or failure to meet regulatory standards. As a manufacturer with strict quality control measures, we ensure that our 4-(2-Hydroxyethyl)benzaldehyde meets rigorous purity requirements, often verified by HPLC and NMR.

When seeking to purchase this critical intermediate, it is advisable to partner with suppliers who:

  • Demonstrate a deep understanding of pharmaceutical synthesis requirements.
  • Maintain robust quality assurance systems and provide comprehensive Certificates of Analysis.
  • Have a stable and scalable manufacturing process to guarantee consistent supply.
  • Offer competitive prices without compromising on quality.

Sourcing from established suppliers in China can offer significant advantages in terms of cost and production capacity, provided stringent quality checks are in place.

Future Prospects and Research Directions

Beyond its established roles, 4-(2-Hydroxyethyl)benzaldehyde holds promise for future pharmaceutical applications. Its potential as a building block for novel anticancer agents and its utility in creating complex heterocyclic structures for various therapeutic targets are areas of ongoing research. Computational studies also play a vital role, helping to predict the biological activity of derivatives and optimize synthetic routes before extensive laboratory work begins.

Conclusion: Your Partner in Pharmaceutical Innovation

4-(2-Hydroxyethyl)benzaldehyde is more than just a chemical intermediate; it is a key enabler of pharmaceutical progress. By providing high-quality material and reliable supply, we empower researchers and manufacturers to develop next-generation therapies. If you are looking to buy this essential compound, we invite you to leverage our expertise as a trusted supplier and manufacturer. Partner with us to accelerate your drug development pipeline.