In the dynamic field of pharmaceutical manufacturing, the selection of advanced chemical intermediates directly impacts the efficiency, purity, and cost-effectiveness of Active Pharmaceutical Ingredient (API) production. Among the most versatile and critical building blocks is 4,6-Dichloropyrimidine (CAS 1193-21-1), a compound that enables complex synthetic pathways for a variety of therapeutic agents.

For pharmaceutical companies and researchers, understanding the properties and applications of 4,6-Dichloropyrimidine is essential when planning API synthesis. This article delves into why this intermediate is so valued and what to consider when you aim to buy it from a trusted manufacturer.

Understanding the Chemistry of 4,6-Dichloropyrimidine

4,6-Dichloropyrimidine is characterized by its pyrimidine ring structure, featuring two chlorine atoms at the 4 and 6 positions. This structural arrangement imparts significant reactivity, making it an ideal starting material or intermediate for various chemical transformations. Its chemical formula is C4H2Cl2N2, with a molecular weight of approximately 148.98 g/mol. As a pharmaceutical intermediate, its typical appearance is a white to light yellow crystal, with high purity levels (often 99.0% MIN) being a critical factor for downstream processes.

Key Applications in Pharmaceutical Synthesis

The utility of 4,6-Dichloropyrimidine spans several important areas within drug development:

  • Antiviral Agents: It is used in the synthesis of nucleoside analogs that can inhibit viral replication, making it a valuable component in the development of antiviral therapies.
  • Anticancer Drugs: Derivatives incorporating the 4,6-dichloropyrimidine moiety have shown promising anticancer activity, leading to its use in the synthesis of novel oncology drugs and chalcone hybrids.
  • Diverse Drug Classes: Its reactivity allows for the introduction of various functional groups through reactions like nucleophilic substitution and Suzuki coupling, facilitating the synthesis of a broad spectrum of drug candidates.

Sourcing High-Purity 4,6-Dichloropyrimidine

When pharmaceutical manufacturers seek to buy 4,6-Dichloropyrimidine, they look for suppliers who can guarantee consistent high purity and reliable supply. Partnering with an experienced manufacturer and supplier based in China, such as NINGBO INNO PHARMCHEM CO.,LTD., offers distinct advantages. These include competitive pricing for bulk orders, adherence to stringent quality control measures, and a robust supply chain that ensures timely delivery of this crucial intermediate.

Accessing accurate technical data, including CoAs and detailed product specifications, is vital for research and development teams. A reputable supplier will provide comprehensive information to support your procurement decisions. The ability to source advanced intermediates like 4,6-Dichloropyrimidine efficiently and affordably is a significant factor in accelerating drug discovery and development timelines.

In summary, 4,6-Dichloropyrimidine is an indispensable intermediate for the pharmaceutical industry. Its chemical versatility and high-purity requirements necessitate careful selection of suppliers. By choosing manufacturers with a proven track record in producing and supplying this critical compound, pharmaceutical companies can ensure the quality and efficiency of their API manufacturing processes, ultimately contributing to the development of life-saving medications.