As a prominent player in the chemical manufacturing landscape, understanding the detailed properties and applications of key intermediates is crucial for both R&D scientists and procurement specialists. 4-Amino-3-chlorophenol Hydrochloride (CAS: 52671-64-4) stands out as a significant organic synthesis intermediate, particularly within the pharmaceutical sector. This article delves into its essential chemical characteristics and the diverse applications it supports, offering valuable insights for those looking to purchase or utilize this compound.

Understanding the Chemical Profile

4-Amino-3-chlorophenol Hydrochloride is characterized by its specific chemical structure, which includes an amino group, a chlorine atom, and a hydroxyl group attached to a benzene ring, in hydrochloride salt form. These functional groups confer upon it a reactivity that is highly desirable in multi-step organic synthesis. The presence of the hydrochloride salt often enhances its stability and ease of handling compared to its free base form.

Key physical properties often include an appearance ranging from off-white to grey to brown crystalline powder. Its melting point, typically around 255 °C with decomposition, indicates a relatively stable solid. While specific solubility data might vary, it is generally understood to be soluble in polar solvents suitable for organic reactions.

Primary Applications in Synthesis

The primary utility of 4-Amino-3-chlorophenol Hydrochloride lies in its role as a precursor or intermediate in the synthesis of more complex molecules. Its applications are predominantly found in:

  • Pharmaceutical Synthesis: It is a well-recognized intermediate in the manufacturing of Active Pharmaceutical Ingredients (APIs). For instance, it is cited as an intermediate in the synthesis of lenvatinib, a vital tyrosine kinase inhibitor used in cancer treatment, and also plays a role in the synthesis of tivozanib. Its precise structure allows for targeted modifications crucial for drug efficacy.
  • Organic Synthesis: Beyond pharmaceuticals, it serves as a valuable building block for a broad spectrum of organic compounds. Researchers and chemists utilize it in various coupling reactions, functional group transformations, and heterocycle formations.
  • Laboratory Research and Development: Its availability from chemical suppliers makes it accessible for academic and industrial R&D laboratories exploring new synthetic routes, developing novel materials, or studying reaction mechanisms.

Procuring High-Quality Material

For any chemical manufacturer or research institution, sourcing reliable intermediates like 4-Amino-3-chlorophenol Hydrochloride is crucial. When searching for a supplier, prioritize those who can provide detailed specifications, purity data, and consistent product quality. Manufacturers often offer bulk quantities and competitive pricing, making them ideal partners for large-scale chemical production. For those looking to buy, consider partnering with established chemical suppliers who can ensure timely delivery and support.

In summary, 4-Amino-3-chlorophenol Hydrochloride is more than just a chemical compound; it is a gateway to developing advanced pharmaceuticals and fine chemicals. Its specific chemical properties and established applications make it an indispensable intermediate for chemists worldwide. By understanding its profile and sourcing it from reputable manufacturers, you can effectively integrate it into your synthesis processes.