4-Aminobenzoic Acid (PABA), known by its CAS number 150-13-0, has a diverse history and application spectrum, particularly in the medical and nutritional fields. While its role as a vitamin in humans is not universally recognized today, its historical associations and specific therapeutic applications continue to make it a compound of interest.

Historical Context: Vitamin B10 and Microbial Synthesis: PABA was once referred to as Vitamin B10 or Vitamin Bx due to its essential role in the synthesis of folic acid by bacteria and plants. Humans, however, do not synthesize folic acid from PABA; instead, they rely on dietary intake of folate. The bacteria residing in the human gut can produce PABA, contributing to the body's folate levels. This biological interplay is the basis for the effectiveness of sulfonamide antibiotics, which inhibit bacterial folate synthesis by acting as PABA antagonists.

Medical Applications: Beyond Nutrition: In medicine, PABA and its derivatives have found specific therapeutic uses. The potassium salt of PABA has been used to treat fibrotic skin disorders like Peyronie's disease. Additionally, PABA has been employed in diagnostic procedures to assess the completeness of 24-hour urine collections, as it is rapidly and almost entirely excreted in urine. Its absorption characteristics also make it a marker in certain pancreatic and liver function tests. Furthermore, PABA derivatives have been investigated for their potential as acetylcholinesterase inhibitors, relevant in the context of neurodegenerative diseases.

Nutritional Supplement Claims and Considerations: Despite not being classified as an essential vitamin for humans, PABA is sometimes marketed as a nutritional supplement, with claims ranging from combating fatigue and irritability to treating skin conditions like vitiligo and premature graying of hair. While research into these benefits is ongoing, it’s important for consumers to approach such claims with caution and consult healthcare professionals.

Sourcing Pharmaceutical-Grade PABA: For medical and research applications, sourcing high-purity 4-Aminobenzoic Acid is critical. Manufacturers require intermediates that meet strict quality standards to ensure the safety and efficacy of their final products. We offer premium-grade 4-Aminobenzoic Acid (≥99% purity), produced under rigorous quality control protocols. As a reliable supplier, we ensure consistent quality, competitive pricing for bulk orders, and comprehensive documentation, including SDS and CoAs, to support medical and research professionals. Our manufacturing capabilities in China allow us to provide a stable and scalable supply.

Partnering for Medical Needs: Choosing the right supplier for medical and nutritional applications is paramount. We understand the importance of quality, purity, and reliability. By partnering with us, you can secure a consistent supply of 4-Aminobenzoic Acid essential for your formulations, research, or diagnostic needs. We invite you to request a quote for our high-quality PABA and discuss how we can support your requirements.