In the dynamic field of organic synthesis, specific chemical intermediates serve as fundamental building blocks for creating complex and novel compounds. 4-Bromo-2-fluoroaniline, identified by its CAS number 367-24-8, is one such critical intermediate. Its unique combination of halogen substituents (bromine and fluorine) on an aniline ring bestows upon it a reactive profile highly sought after in various synthesis pathways. For R&D scientists and chemical procurement specialists, understanding its applications and how to efficiently buy this compound is vital for project success.

Chemical Profile and Key Properties

4-Bromo-2-fluoroaniline is typically supplied as a beige to light brown powder, with a high purity assay, often exceeding 99.5%. Its molecular formula is C6H5BrFN, and its molecular weight is approximately 190.01 g/mol. The melting point of this compound falls within the range of 40-42°C, and its boiling point is approximately 103-108°C at reduced pressure. These physical and chemical characteristics are essential for handling, storage, and reaction planning. For those looking to buy this organic synthesis reagent, verifying these specifications from a trusted manufacturer ensures optimal performance in your reactions.

Applications in Synthesis and Pharmaceuticals

The primary utility of 4-Bromo-2-fluoroaniline lies in its role as a versatile intermediate in organic synthesis. It serves as a crucial building block for creating more complex molecular structures. Its most prominent application is in the pharmaceutical industry, where it is used in the multi-step synthesis of advanced pharmaceutical intermediates. A significant example is its use in the manufacturing of Vandetanib, a drug employed in treating certain types of cancer. This linkage highlights the compound's importance for developing life-saving therapies and underscores the demand for consistent, high-quality supply. Researchers also utilize it for laboratory-scale synthesis of new chemical entities, exploring novel reactions and material properties.

Sourcing Strategies: Finding a Reliable Manufacturer

When deciding to buy 4-Bromo-2-fluoroaniline, identifying a reliable manufacturer or supplier is paramount. China is a primary source for this chemical, offering competitive pricing and a vast production capacity. Procurement professionals should look for manufacturers with a strong track record, certifications (like ISO), and transparent quality control processes. Engaging with suppliers that can provide detailed Certificates of Analysis (CoA), including purity and assay data, is essential. Understanding the supplier's ability to consistently deliver, even for large-scale orders, is also a key consideration. Competitive 4-Bromo-2-fluoroaniline price points are often available, but should always be evaluated alongside the supplier's reliability and product quality.

Efficient Purchasing Process

To streamline the procurement of 4-Bromo-2-fluoroaniline, a systematic approach is recommended. Firstly, clearly define your project requirements: quantity, purity, and any specific packaging needs. Secondly, research potential suppliers, comparing their product offerings, pricing, and service capabilities. Requesting samples can be beneficial for initial evaluation. Finally, establish a clear communication channel with your chosen supplier to ensure timely delivery and address any technical queries. For any chemist or procurement manager, having a dependable source for this key organic synthesis intermediate can significantly accelerate research and development timelines.

In summary, 4-Bromo-2-fluoroaniline is a critical intermediate for both pharmaceutical development and broader organic synthesis applications. By prioritizing purity, understanding its chemical properties, and partnering with reputable manufacturers, buyers can ensure they obtain this vital compound for their advanced chemical projects.