For chemists and procurement specialists in the pharmaceutical and advanced materials industries, understanding the detailed specifications and reliable sourcing of key chemical intermediates is crucial. 4-Bromobenzo[b]thiophene, identified by CAS number 5118-13-8, is a prime example of such a compound, renowned for its role in synthesizing vital pharmaceuticals like Brexpiprazole and its emerging applications in material science.

This article serves as a guide to the essential aspects of 4-Bromobenzo[b]thiophene. We will cover its key physicochemical properties, its primary industrial applications, and provide practical advice for procurement, focusing on what buyers should look for when sourcing from manufacturers.

Physicochemical Properties:

  • Chemical Name: 4-Bromobenzo[b]thiophene
  • CAS Number: 5118-13-8
  • Molecular Formula: C8H5BrS
  • Molecular Weight: 213.09 g/mol
  • Appearance: Typically an off-white to white crystalline powder or solid.
  • Purity: High purity is essential, often specified as ≥98% by HPLC.
  • Melting Point: Ranges between 110–115°C, indicating it is a solid at room temperature.
  • Solubility: Generally soluble in organic solvents like DMSO and THF, and insoluble in water.
  • Stability: Stable under ambient conditions but should be protected from prolonged light exposure and stored in cool, dry environments.

Key Applications:

The primary driver for the demand of 4-Bromobenzo[b]thiophene is its critical function as an intermediate in the synthesis of Brexpiprazole, a significant medication used in psychiatric treatments. Its well-defined chemical structure allows for efficient subsequent synthetic steps. Beyond pharmaceuticals, its unique properties also make it valuable in material science, acting as a building block for organic electronics such as OLEDs and advanced semiconductor materials. Research chemists also utilize it in various cross-coupling reactions, demonstrating its versatility.

Procurement Considerations:

When you intend to buy 4-Bromobenzo[b]thiophene, several factors are crucial for ensuring a successful procurement process:

  • Purity: Always verify the purity levels (e.g., ≥98% HPLC) and the testing methodology. A trusted 4-Bromobenzo[b]thiophene supplier will provide certificates of analysis (CoA) with detailed batch-specific data.
  • Manufacturer Reputation: Choose manufacturers with a strong reputation for quality control and consistent production. Sourcing from a reliable manufacturer in China often provides a good balance of quality and cost-effectiveness.
  • Packaging and Storage: Inquire about standard packaging (e.g., 25 kg drums) and storage recommendations to maintain product integrity.
  • Technical Support: Access to technical support can be invaluable for R&D and process optimization.
  • Pricing and Lead Times: Compare quotes and lead times from different suppliers to secure the best possible 4-Bromobenzo[b]thiophene price and ensure timely delivery.

In conclusion, 4-Bromobenzo[b]thiophene is a high-value chemical intermediate with significant applications. By understanding its properties and adopting a strategic procurement approach, businesses can secure a consistent and high-quality supply, thereby supporting their critical manufacturing and research endeavors.