In the intricate world of pharmaceutical research and development, specific chemical intermediates play pivotal roles in constructing complex molecules. 4-Bromobenzylamine Hydrochloride (CAS: 26177-44-6) stands out as a versatile building block, widely utilized by organic chemists and pharmaceutical scientists. This article delves into its chemical characteristics, common synthesis pathways, and its crucial applications within the pharmaceutical sector. Understanding these aspects is vital for researchers looking to buy 4-Bromobenzylamine Hydrochloride for their synthetic projects.

Chemical Profile of 4-Bromobenzylamine Hydrochloride

4-Bromobenzylamine Hydrochloride, with the molecular formula C7H9BrClN and a molecular weight of 222.51 g/mol, is typically encountered as a white to off-white crystalline solid. Its melting point is notably high, often cited in the range of 274-276 °C (lit.). The presence of the bromine atom on the phenyl ring and the primary amine group (as a hydrochloride salt) provides reactive sites for a multitude of chemical transformations. This makes it an excellent starting material for introducing the 4-bromobenzyl moiety into larger molecules. Its stability as a hydrochloride salt also simplifies handling and storage in laboratory settings, which is a significant advantage when sourcing this compound.

Synthesis and Manufacturing Aspects

The synthesis of 4-Bromobenzylamine Hydrochloride typically involves the reduction of 4-bromobenzonitrile or 4-bromobenzaldehyde oxime, followed by treatment with hydrochloric acid. Manufacturers in China often optimize these processes for yield and purity. When you consider purchasing from a manufacturer, inquiring about their synthesis route and quality control measures can provide assurance. The availability of this intermediate from reliable suppliers in China means that researchers can readily access it for both small-scale R&D and larger-scale manufacturing processes. The competitive pricing offered by these manufacturers also supports budget-conscious research efforts.

Applications in Pharmaceutical Development

The primary utility of 4-Bromobenzylamine Hydrochloride lies in its role as a key intermediate for synthesizing various pharmaceutical compounds. It serves as a precursor for:

  • Active Pharmaceutical Ingredients (APIs): It can be incorporated into the structure of drugs targeting a range of conditions. The bromobenzyl group can be further functionalized or act as a key structural element.
  • Novel Drug Discovery: Researchers utilize it to build libraries of potential drug candidates, exploring new chemical entities with desired biological activities.
  • Fragment-Based Drug Design: As a well-defined chemical fragment, it can be used in screening assays to identify promising starting points for drug development.
  • Process Development: Its predictable reactivity makes it valuable for developing robust and scalable synthetic routes for drug manufacturing.

For any scientist or procurement specialist looking to buy 4-Bromobenzylamine Hydrochloride, understanding its reactivity and common applications ensures that it is the right choice for their specific synthetic needs. Partnering with a dedicated supplier in China can provide access to this essential chemical with consistent quality and support.