4'-Bromobutyrophenone (CAS 4981-64-0): Properties, Synthesis, and Market Availability
4'-Bromobutyrophenone, bearing the CAS number 4981-64-0, is a compound that is frequently encountered in synthetic organic chemistry. Its well-defined physical and chemical properties, coupled with its accessibility, make it a valuable reagent and intermediate for a wide array of applications, particularly in the fine chemical and pharmaceutical industries.
Physically, 4'-Bromobutyrophenone is typically described as a white to off-white solid. This appearance is consistent with many organic compounds of similar molecular weight and structure. Its molecular formula is C10H11BrO, and its molecular weight is approximately 227.10 g/mol. These fundamental characteristics are essential for understanding its behavior in chemical reactions and for calculating reaction stoichiometry.
The synthesis of 4'-Bromobutyrophenone commonly involves the Friedel-Crafts acylation reaction between bromobenzene and butyryl chloride. This reaction, catalyzed by a Lewis acid such as aluminum chloride, is a standard method for producing aryl ketones. The efficiency and yield of this synthesis route contribute to the compound's market availability and cost-effectiveness. Many fine chemical suppliers, especially those located in China, offer 4'-Bromobutyrophenone, making it relatively easy to buy. When sourcing, attention should be paid to purity levels, with many suppliers offering grades suitable for demanding applications.
In terms of its chemical reactivity, the bromine atom on the phenyl ring makes 4'-Bromobutyrophenone amenable to various palladium-catalyzed cross-coupling reactions. These reactions are instrumental in forming new carbon-carbon bonds, a cornerstone of modern organic synthesis. The carbonyl group also offers further synthetic handles for transformations such as reduction to an alcohol or reaction with Grignard reagents. These reactive sites underscore its importance as a chemical building block.
Safety considerations for 4'-Bromobutyrophenone include potential hazards such as being harmful if swallowed and causing skin and eye irritation. Standard laboratory safety practices, including the use of PPE and working in a well-ventilated area, are therefore essential. The market availability of this compound from multiple suppliers ensures that researchers and manufacturers can readily access it for their projects, supporting innovation in various chemical disciplines.
In essence, 4'-Bromobutyrophenone is a compound whose predictable properties, established synthesis methods, and wide market availability solidify its role as a key intermediate in the chemical industry.
Physically, 4'-Bromobutyrophenone is typically described as a white to off-white solid. This appearance is consistent with many organic compounds of similar molecular weight and structure. Its molecular formula is C10H11BrO, and its molecular weight is approximately 227.10 g/mol. These fundamental characteristics are essential for understanding its behavior in chemical reactions and for calculating reaction stoichiometry.
The synthesis of 4'-Bromobutyrophenone commonly involves the Friedel-Crafts acylation reaction between bromobenzene and butyryl chloride. This reaction, catalyzed by a Lewis acid such as aluminum chloride, is a standard method for producing aryl ketones. The efficiency and yield of this synthesis route contribute to the compound's market availability and cost-effectiveness. Many fine chemical suppliers, especially those located in China, offer 4'-Bromobutyrophenone, making it relatively easy to buy. When sourcing, attention should be paid to purity levels, with many suppliers offering grades suitable for demanding applications.
In terms of its chemical reactivity, the bromine atom on the phenyl ring makes 4'-Bromobutyrophenone amenable to various palladium-catalyzed cross-coupling reactions. These reactions are instrumental in forming new carbon-carbon bonds, a cornerstone of modern organic synthesis. The carbonyl group also offers further synthetic handles for transformations such as reduction to an alcohol or reaction with Grignard reagents. These reactive sites underscore its importance as a chemical building block.
Safety considerations for 4'-Bromobutyrophenone include potential hazards such as being harmful if swallowed and causing skin and eye irritation. Standard laboratory safety practices, including the use of PPE and working in a well-ventilated area, are therefore essential. The market availability of this compound from multiple suppliers ensures that researchers and manufacturers can readily access it for their projects, supporting innovation in various chemical disciplines.
In essence, 4'-Bromobutyrophenone is a compound whose predictable properties, established synthesis methods, and wide market availability solidify its role as a key intermediate in the chemical industry.
Perspectives & Insights
Future Origin 2025
“Standard laboratory safety practices, including the use of PPE and working in a well-ventilated area, are therefore essential.”
Core Analyst 01
“The market availability of this compound from multiple suppliers ensures that researchers and manufacturers can readily access it for their projects, supporting innovation in various chemical disciplines.”
Silicon Seeker One
“In essence, 4'-Bromobutyrophenone is a compound whose predictable properties, established synthesis methods, and wide market availability solidify its role as a key intermediate in the chemical industry.”