In the intricate world of organic synthesis and pharmaceutical manufacturing, the role of specialized chemical intermediates cannot be overstated. These compounds serve as the essential building blocks that enable chemists to construct complex molecular architectures, leading to the development of life-saving drugs and advanced materials. Among these critical intermediates is 4-Bromofluorobenzene (CAS 460-00-4), a versatile compound whose unique chemical structure makes it highly valuable for a range of synthetic applications. For chemists and researchers seeking to buy 4-Bromofluorobenzene, understanding its properties and applications is the first step towards successful procurement.

The Chemistry of 4-Bromofluorobenzene

4-Bromofluorobenzene is an aromatic halide, specifically a brominated and fluorinated derivative of benzene. Its molecular formula is C6H4BrF, and its CAS number is 460-00-4. The molecule features a benzene ring with a bromine atom and a fluorine atom attached at opposite positions (para-substitution). This specific substitution pattern grants it distinct reactivity profiles. The bromine atom is a good leaving group and can participate in various metal-catalyzed cross-coupling reactions, such as Suzuki, Heck, and Sonogashira couplings, which are fundamental in forming new carbon-carbon bonds. The fluorine atom, being highly electronegative, influences the electron distribution within the aromatic ring, affecting its reactivity and the physical properties of molecules into which it is incorporated. This duality makes 4-Bromofluorobenzene an attractive intermediate for chemists looking to introduce specific functionalities into their target molecules.

Applications in Pharmaceutical and Chemical Industries

The primary application of 4-Bromofluorobenzene is as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs). Its structure is particularly useful for creating complex drug molecules, including certain classes of antipsychotic medications, where precise molecular construction is vital. Researchers developing novel APIs often seek to buy 4-Bromofluorobenzene to leverage its reactivity in creating target structures efficiently.

Beyond pharmaceuticals, 4-Bromofluorobenzene can also find applications in the development of agrochemicals, specialized polymers, and electronic materials, where its unique aromatic and halogenated features can impart desired properties. For laboratories and R&D departments, reliable access to high-quality CAS 460-00-4 is crucial for reproducible experimental results and successful project progression.

Sourcing and Quality Assurance

When procuring 4-Bromofluorobenzene, it is essential to source from a reputable manufacturer in China or other trusted global suppliers. Ensuring the quality of the intermediate, often specified by purity levels like USP, BP, or FCC, is paramount. A reliable supplier of chemical intermediates will provide comprehensive documentation, including a Certificate of Analysis (CoA) detailing the batch-specific purity and any impurities. Comparing prices for 1-bromo-4-fluorobenzene is part of the procurement process, but should be balanced with the assurance of consistent quality and timely delivery.

NINGBO INNO PHARMCHEM CO.,LTD. is a leading manufacturer of 4-Bromofluorobenzene, dedicated to providing high-purity intermediates to the global market. We understand the critical role this compound plays in synthesis and are committed to being your trusted supplier, offering competitive pricing and reliable service to support your chemical synthesis needs.