In the vast realm of organic chemistry, certain molecules serve as foundational building blocks, enabling the creation of complex and valuable compounds. 4-Chloro-2-nitroanisole, identified by its CAS number 89-21-4, is one such critical chemical intermediate. Its unique structural features and reactivity make it indispensable for researchers and manufacturers seeking to develop new materials, pharmaceuticals, and agrochemicals. Understanding its properties and applications is key for anyone looking to procure or utilize this compound effectively.

Chemical Identity and Physical Characteristics

4-Chloro-2-nitroanisole, with the molecular formula C7H6ClNO3, possesses a molecular weight of 187.58 g/mol. Its typical appearance is that of a yellow powder, a characteristic that aids in its identification. A crucial physical property is its melting point, which usually falls within the range of 97-99°C. This specific melting range indicates a relatively stable solid compound under ambient conditions. The presence of a chlorine atom, a nitro group, and a methoxy group on the benzene ring contributes to its distinct chemical reactivity and makes it a versatile starting material for various synthetic routes.

Key Applications in Synthesis

The primary utility of 4-Chloro-2-nitroanisole lies in its role as a chemical intermediate. This means it is not typically the final product but a precursor used in multi-step synthesis processes. Its functional groups allow for a range of chemical reactions:

  • Nucleophilic Aromatic Substitution: The chlorine atom can be displaced by various nucleophiles, allowing for the introduction of different functional groups onto the aromatic ring.
  • Reduction of the Nitro Group: The nitro group can be reduced to an amine, opening pathways to aniline derivatives, which are crucial in dye, pharmaceutical, and polymer synthesis.
  • Reactions involving the Methoxy Group: While generally stable, the methoxy group can also participate in certain reactions under specific conditions.

These reactions make 4-Chloro-2-nitroanisole particularly valuable in the synthesis of:

  • Pharmaceutical Intermediates: It serves as a building block for active pharmaceutical ingredients (APIs) and complex drug molecules.
  • Agrochemicals: Its derivatives can be found in the synthesis of certain pesticides and herbicides.
  • Dyes and Pigments: Aromatic nitro compounds are often precursors in the colorants industry.
  • Specialty Chemicals: It is used in the production of various fine chemicals for research and industrial applications.

Sourcing and Procurement Considerations

When businesses look to buy 4-Chloro-2-nitroanisole, sourcing from reliable chemical intermediate suppliers, particularly from China, is a common strategy due to competitive pricing and manufacturing capabilities. Ensuring high purity (often 97% or higher) and consistent quality from a trusted manufacturer is paramount. Buyers should always request a Certificate of Analysis (CoA) to verify the product's specifications, including its CAS number (89-21-4) and purity levels. Understanding the market price for C7H6ClNO3 helps in negotiating competitive deals.

Conclusion

4-Chloro-2-nitroanisole (CAS 89-21-4) is a testament to the importance of versatile chemical intermediates in driving innovation. Its well-defined properties and reactivity enable a broad spectrum of applications, from life-saving pharmaceuticals to advanced materials. For companies aiming to procure this compound, a focus on quality, supplier reliability, and understanding its technical specifications will ensure successful integration into their synthesis workflows. It remains a key molecule for chemists and formulators worldwide.