In the intricate world of organic synthesis, the availability of high-quality building blocks is critical for innovation. 4-Ethoxybenzoic Acid (CAS 619-86-3) is one such compound, prized for its structural features that lend themselves to a wide array of synthetic transformations. Understanding its properties and applications can help chemists and researchers optimize their synthetic routes and achieve desired molecular targets.

Understanding 4-Ethoxybenzoic Acid's Structure and Properties

4-Ethoxybenzoic Acid is an aromatic carboxylic acid characterized by an ethoxy group (-OCH2CH3) attached at the para position of a benzoic acid ring. This structure imparts specific chemical and physical properties, including a melting point around 197-199 °C and a molecular weight of 166.17 g/mol. It typically appears as a white to off-white crystalline powder. Its reactivity stems from both the carboxylic acid group, which can undergo esterification, amidation, and reduction, and the aromatic ring, which can participate in electrophilic aromatic substitution reactions. The ethoxy group influences its solubility and electronic properties, making it a versatile synthon.

Applications in Organic Synthesis

As a key intermediate, 4-Ethoxybenzoic Acid is instrumental in various organic synthesis projects:

  • Ester and Amide Formation: The carboxylic acid functionality readily reacts with alcohols and amines to form esters and amides, which are common functional groups in pharmaceuticals and materials.
  • Aromatic Substitutions: The electron-donating ethoxy group can direct further substitutions on the aromatic ring, allowing for the creation of more complex substituted aromatic compounds.
  • Precursor to APIs: It serves as a starting material or intermediate in the synthesis of several Active Pharmaceutical Ingredients (APIs) and their precursors, contributing to the development of new drugs.
  • Material Science: Its derivatives can be incorporated into polymers or used in the development of functional materials, leveraging its aromatic structure and ether linkage.

Sourcing Strategies for Researchers

For academic and industrial researchers, buying 4-Ethoxybenzoic Acid requires careful consideration of suppliers. When you need to purchase this compound, prioritize suppliers who offer high purity (e.g., ≥99% by HPLC) and provide comprehensive documentation like Safety Data Sheets (SDS) and Certificates of Analysis (CoA). Companies specializing in fine chemicals and intermediates often have competitive prices for laboratory quantities, allowing researchers to procure materials efficiently. Many manufacturers in China are established suppliers for this chemical, offering global shipping and reliable service. Exploring options from multiple suppliers can help you secure the best value.

By understanding the chemical utility and sourcing best practices for 4-Ethoxybenzoic Acid, chemists can effectively integrate this valuable compound into their synthetic endeavors, paving the way for new discoveries and product innovations in the chemical and pharmaceutical sectors.