The chemical industry constantly seeks versatile building blocks for innovation, particularly in pharmaceuticals and advanced materials. 4-Fluorocinnamic Acid (CAS 459-32-5) stands out as a crucial intermediate, valued for its unique structural features and reactivity. As a specialized supplier, we provide insights into the applications of this compound and guide potential buyers on how to procure it effectively.

Chemical Profile of 4-Fluorocinnamic Acid

4-Fluorocinnamic Acid, with the molecular formula C9H7FO2 and CAS number 459-32-5, is an organic compound characterized by a cinnamic acid backbone with a fluorine atom substituted at the para position of the phenyl ring. It typically presents as a white to light yellow crystalline powder, with a melting point around 209-210°C. The presence of the fluorine atom can significantly influence the electronic properties and metabolic stability of molecules derived from it, making it an attractive component in drug design and development. Its structure facilitates various chemical transformations, enabling chemists to build complex molecular architectures.

Key Applications in Pharmaceutical Synthesis

The primary utility of 4-Fluorocinnamic Acid lies in its role as a pharmaceutical intermediate. It serves as a key starting material or building block for the synthesis of a wide range of Active Pharmaceutical Ingredients (APIs). Researchers often incorporate fluorinated motifs into drug candidates to enhance their bioavailability, metabolic stability, and lipophilicity. By acting as a fluorinated phenylpropanoid precursor, 4-Fluorocinnamic Acid allows for the precise introduction of this desirable functionality into target drug molecules. For companies engaged in drug discovery and development, securing a reliable supply of high-purity 4-Fluorocinnamic Acid from a reputable manufacturer is critical for their research pipelines.

Role in Organic Synthesis and Research

Beyond pharmaceuticals, 4-Fluorocinnamic Acid is also utilized in broader organic synthesis and academic research. Its carboxylic acid and alkene functionalities provide multiple reactive sites for various organic reactions, including esterification, amidation, and addition reactions across the double bond. It has been documented for its use in preparing specialized growth media for certain microorganisms, contributing to biochemical studies. Scientists exploring novel organic compounds, functional materials, or specific reaction pathways often find 4-Fluorocinnamic Acid to be an indispensable reagent. When seeking to buy this compound, it's advisable to work with suppliers who can provide detailed product specifications and ensure consistent batch-to-batch quality.

Sourcing Strategies for Buyers

Procurement specialists and researchers seeking to purchase 4-Fluorocinnamic Acid should prioritize suppliers offering high purity (e.g., 98%+) and competitive pricing. Manufacturers based in China are often leading providers, offering excellent value for this intermediate. When evaluating suppliers, consider factors such as:

  • Product Specifications: Verify purity, appearance, and CAS number.
  • Supplier Reputation: Look for established companies with positive reviews and a strong track record.
  • Availability: Ensure the supplier can meet your required quantities, from small lab batches to larger production volumes.
  • Customer Support: Responsive communication and technical assistance are vital.

By engaging with trusted manufacturers and suppliers, researchers and production managers can effectively source 4-Fluorocinnamic Acid to drive their projects forward, whether in pharmaceutical development or advanced chemical synthesis. Consider requesting a quote or a free sample to assess quality before making a purchase decision.