In the precise landscape of chemical manufacturing and pharmaceutical development, understanding the specifications and applications of raw materials and intermediates is paramount. 4-Hydrazinobenzenesulfonamide, identified by CAS number 4392-54-5, is a compound of significant interest, particularly within the pharmaceutical industry, due to its critical role in the synthesis of important APIs.

Chemical Identity and Physical Properties

4-Hydrazinobenzenesulfonamide is an organic compound with the molecular formula C6H9N3O2S and a molecular weight of approximately 187.22 g/mol. Its chemical structure features a benzene ring substituted with a hydrazino group and a sulfonamide group. Physically, it is described as an off-white to light beige powder. Key physical properties include a melting point typically ranging from 158-159°C. The compound's density is approximately 1.5 g/cm³.

Key Specifications for Industrial Use

For its use as a pharmaceutical intermediate, stringent quality specifications are essential. The most critical parameter is its purity, usually requiring an assay of ≥98.0%. This high level of purity ensures that subsequent chemical reactions proceed efficiently and that the final drug product meets strict quality standards. Manufacturers commonly package 4-Hydrazinobenzenesulfonamide in 25 kg drums, with options for customization based on customer requirements. Proper storage in a cool, ventilated place is recommended to maintain its chemical integrity.

Primary Application: Intermediate for Celecoxib

The foremost application of 4-Hydrazinobenzenesulfonamide is its indispensable role as a key intermediate in the synthesis of Celecoxib. Celecoxib is a selective COX-2 inhibitor, widely used as a nonsteroidal anti-inflammatory drug (NSAID) for managing pain and inflammation associated with various conditions, including arthritis. The chemical structure of 4-Hydrazinobenzenesulfonamide provides the necessary reactive functionality for its incorporation into the Celecoxib molecule during its complex manufacturing process. Pharmaceutical companies looking to procure this intermediate for Celecoxib production will find numerous manufacturers globally, with a strong presence in China offering competitive pricing and a reliable supply.

Other Potential Applications and Research Interest

Beyond its primary role in Celecoxib synthesis, 4-Hydrazinobenzenesulfonamide may also find applications in other areas of organic synthesis. Its reactive functional groups make it a valuable building block for researchers developing novel chemical compounds, potentially for new drug candidates or other fine chemical applications. For scientists exploring new synthetic routes, understanding the specifications and reliable availability from manufacturers is crucial.

In conclusion, 4-Hydrazinobenzenesulfonamide (CAS 4392-54-5) is a high-value chemical intermediate, critical for the pharmaceutical industry. Its precise specifications, particularly purity, and its established application in Celecoxib synthesis, make it a sought-after material for manufacturers and researchers. Exploring options from reputable suppliers ensures access to quality material essential for successful chemical development and production.