For R&D scientists, formulation chemists, and procurement managers in the pharmaceutical industry, a deep understanding of chemical intermediates is crucial. 4-Hydrazinobenzoic Acid (CAS 619-67-0) stands out as a vital compound, primarily recognized for its indispensable role in the synthesis of Deferasirox, a critical medication for managing iron overload. This article explores the technical specifications of 4-Hydrazinobenzoic Acid and its applications, offering valuable information for those looking to buy this essential chemical.

Key Technical Specifications of 4-Hydrazinobenzoic Acid
The utility of any chemical intermediate in pharmaceutical synthesis hinges on its precise technical specifications. For 4-Hydrazinobenzoic Acid, the following parameters are of particular importance:

  • Chemical Name: 4-Hydrazinobenzoic acid
  • CAS Number: 619-67-0
  • Molecular Formula: C7H8N2O2
  • Molecular Weight: 152.15 g/mol
  • Appearance: Typically described as a yellow-brown crystal or light yellow to light brown powder. The precise appearance can depend on the purity and crystallization process.
  • Assay (Purity): A critical specification, usually requiring a minimum purity of ≥99.0% when analyzed by High-Performance Liquid Chromatography (HPLC). This high purity is non-negotiable for pharmaceutical applications to ensure the quality of the final API.
  • Melting Point: Generally reported as 218 °C (with decomposition), indicating its solid state and thermal behavior.
  • Other Parameters: Specifications may also include limits on ash content (e.g., ≤3.0%), water content, and absence of specific known impurities.

These specifications are meticulously controlled by reputable manufacturers and suppliers to meet the stringent demands of the pharmaceutical sector. When sourcing this intermediate, always request a detailed Certificate of Analysis (CoA) to verify these critical parameters.

Vital Applications in Pharmaceutical Synthesis
The primary and most significant application of 4-Hydrazinobenzoic Acid is its function as a key intermediate in the synthesis of Deferasirox. Deferasirox is a potent iron chelator used to treat patients suffering from chronic iron overload, a condition common in individuals who receive frequent blood transfusions for diseases like thalassemia. The chemical structure of 4-Hydrazinobenzoic Acid provides the necessary reactive groups to facilitate the formation of the Deferasirox molecule.

Beyond its direct role in Deferasirox synthesis, 4-Hydrazinobenzoic Acid also finds application in:

  • Research and Development: As a versatile building block in organic chemistry, it can be used in the development of new pharmaceutical candidates and specialty chemicals.
  • Quality Control: It serves as a reference standard for analytical testing to ensure the purity and quality of Deferasirox batches, helping to identify and quantify any residual starting material or related impurities.

Where to Buy 4-Hydrazinobenzoic Acid
For researchers and manufacturers seeking reliable sources, partnering with experienced chemical suppliers is key. Companies like NINGBO INNO PHARMCHEM CO.,LTD. are dedicated to providing high-quality 4-Hydrazinobenzoic Acid with detailed technical specifications and competitive pricing. Engaging with such manufacturers ensures that your procurement process is efficient and that you receive a product that meets the highest pharmaceutical standards.

In summary, the precise technical specifications of 4-Hydrazinobenzoic Acid, particularly its high purity, are fundamental to its successful application in Deferasirox synthesis. Thoroughly vetting suppliers and understanding these specifications is crucial for any organization looking to procure this essential pharmaceutical intermediate.