For professionals in the chemical and pharmaceutical industries, a deep understanding of chemical compounds, their properties, synthesis, and applications is vital. 4-Hydroxythiobenzamide (CAS 25984-63-8) is one such compound that plays a significant role, primarily as a pharmaceutical intermediate, but also in various research and development endeavors. This article delves into the essential aspects of this chemical, offering insights for procurement managers and R&D scientists looking to source it.

Understanding the Chemical Profile
4-Hydroxythiobenzamide is characterized by its molecular formula C7H7NOS and a molecular weight of 153.20. It typically appears as a grey white or light yellow powder. Its melting point is generally reported around 191-193 °C (with decomposition). While specific solubility details may vary, it is often soluble in solvents like DMSO and Methanol. The compound's chemical structure is critical to its function, featuring a hydroxyl group that can participate in various reactions, and a thioamide group that imparts unique reactivity. For many suppliers, a purity level of ≥99% is standard, ensuring its suitability for demanding applications.

Synthesis Pathways
The synthesis of 4-Hydroxythiobenzamide is a key process for its availability as a commercial chemical. One common method involves the reaction of 4-cyanophenol with sodium hydrosulfide in the presence of a secondary amine and subsequently with an organic weak acid. This process allows for the efficient production of the intermediate, making it accessible for industrial use. Manufacturers continuously work to optimize these synthesis routes to enhance yield, purity, and cost-effectiveness, ensuring a stable supply for buyers.

Key Applications and Market Significance
The primary application driving the demand for 4-Hydroxythiobenzamide is its role as a crucial intermediate in the synthesis of Febuxostat, a widely prescribed medication for gout. Its utility extends to the development of other potential therapeutics, such as CDK5 inhibitors, which are being researched for neurodegenerative diseases like Alzheimer's. Furthermore, its structure makes it a valuable compound for exploration in catalysis and materials science, contributing to ongoing innovation in these fields. For researchers and manufacturers, purchasing this compound means investing in a critical component for advanced chemical synthesis.

Sourcing 4-Hydroxythiobenzamide: Partnering with NINGBO INNO PHARMCHEM CO.,LTD.
NINGBO INNO PHARMCHEM CO.,LTD. is a leading manufacturer and supplier specializing in high-quality chemical intermediates, including 4-Hydroxythiobenzamide. We are committed to providing our clients with products that meet rigorous purity standards and are competitively priced, especially for bulk orders. Our expertise in chemical synthesis and our dedication to customer satisfaction make us a reliable partner for your procurement needs. We invite procurement managers and R&D scientists to contact us to discuss pricing, availability, and technical specifications. Secure a dependable supply of 4-Hydroxythiobenzamide for your critical applications from a trusted manufacturer.

Understanding the properties, synthesis, and applications of 4-Hydroxythiobenzamide empowers informed sourcing decisions, ensuring the success of your chemical and pharmaceutical endeavors.