In the intricate world of pharmaceutical manufacturing, the quality of raw materials and intermediates is not merely a specification; it's the bedrock of product efficacy and patient safety. For manufacturers producing Celecoxib, a vital nonsteroidal anti-inflammatory drug (NSAID), securing a consistent and high-quality supply of 4-Sulfonamide-phenylhydrazine hydrochloride (CAS: 27918-19-0) is a non-negotiable aspect of their production chain. This article aims to guide procurement professionals and R&D scientists in understanding the critical factors when purchasing this essential chemical intermediate.

Understanding the Chemical Profile

4-Sulfonamide-phenylhydrazine hydrochloride typically presents as an off-white to yellow or orange crystalline powder. Its molecular formula, C6H9N3O2S, and molecular weight of 187.220 (for the free base, hydrochloride salt is 223.68) are key identifiers. Critically for API synthesis, its assay is usually specified as ≥98.0% via High-Performance Liquid Chromatography (HPLC). This high purity is crucial because it directly impacts the efficiency of the subsequent reaction steps in Celecoxib synthesis, minimizing the presence of potential impurities that could compromise the final API.

The Strategic Role of Reliable Suppliers

When procurement managers search for suppliers, the focus is on reliability, quality assurance, and competitive pricing. Manufacturers like NINGBO INNO PHARMCHEM CO.,LTD., operating as both a manufacturer and supplier, offer distinct advantages. By sourcing directly from such entities, pharmaceutical companies can often achieve better pricing and ensure more stable lead times, especially when looking to buy in bulk quantities, such as 25 kg drums. The ability to source from China, a hub for chemical synthesis, presents an opportunity to tap into advanced manufacturing capabilities and a vast supplier network.

Key Decision Factors for Purchase

  • Product Specifications: Always cross-reference the product's appearance, assay, CAS number (27918-19-0), and any other critical physical/chemical properties against your R&D and manufacturing requirements.
  • Manufacturing Excellence: Prioritize suppliers who operate under stringent quality control measures and can provide comprehensive documentation.
  • Supply Chain Stability: Evaluate a supplier's capacity to meet your ongoing demand. Long-term partnerships are built on consistent supply and transparent communication.
  • Technical Support: Access to technical expertise from the manufacturer can be invaluable for troubleshooting and process optimization.

For any pharmaceutical company engaged in Celecoxib production, understanding the importance of sourcing quality 4-Sulfonamide-phenylhydrazine hydrochloride is the first step towards a successful manufacturing outcome. Partnering with reputable chemical manufacturers in China can offer a strategic advantage in terms of both quality and cost-effectiveness.