In the intricate world of drug discovery and advanced organic synthesis, certain chemical intermediates stand out for their versatility and the unique properties they impart to final products. 4-Trifluoromethoxyphenylboronic Acid (CAS 139301-27-2) is one such indispensable compound. As a leading manufacturer and supplier, we are proud to offer this high-purity material, essential for researchers aiming to innovate and develop new therapeutic agents. This article highlights its critical roles and why chemists worldwide choose to buy it from reliable sources.

The structure of 4-Trifluoromethoxyphenylboronic Acid is key to its utility. The boronic acid group (-B(OH)2) is a highly reactive functional group, readily participating in palladium-catalyzed cross-coupling reactions, most notably the Suzuki-Miyaura coupling. This reaction is a cornerstone of modern organic synthesis, enabling the facile formation of carbon-carbon bonds to construct complex molecular architectures. When you purchase this compound, you are acquiring a tool that significantly broadens the scope of possible molecular designs.

The trifluoromethoxy (-OCF3) group is another critical feature. Fluorine atoms, particularly in trifluoromethyl or trifluoromethoxy groups, are known to dramatically alter the physicochemical properties of organic molecules. They can enhance metabolic stability, increase lipophilicity (aiding cell membrane penetration), modify electronic distribution, and improve binding affinity to biological targets. These effects are invaluable in the design of drug candidates with improved efficacy, bioavailability, and reduced side effects. Therefore, for pharmaceutical R&D, securing a consistent supplier of such functionalized intermediates is paramount.

One of the primary applications of 4-Trifluoromethoxyphenylboronic Acid is in the synthesis of kinase inhibitors. Kinases are enzymes that play crucial roles in cellular signaling pathways, and their dysregulation is implicated in numerous diseases, including cancer. By using this boronic acid derivative, researchers can synthesize novel inhibitors that target specific kinases, offering potential treatments for various oncological conditions. The ability to precisely modify drug candidates by incorporating the trifluoromethoxy phenyl moiety makes this intermediate a high-value commodity for anyone looking to buy cutting-edge pharmaceutical building blocks.

Beyond oncology, this boronic acid finds use in developing other classes of therapeutic agents. Research has explored its application in creating:

  • Lactate dehydrogenase (LDH) inhibitors for combating cancer cell proliferation.
  • Nitro-phenoxybenzoic acid derivatives for PAI-1 (plasminogen activator inhibitor-1) inhibition, relevant for cardiovascular and thrombotic diseases.
  • Analogs of PA-824, an antituberculosis drug, potentially leading to new treatments for infectious diseases.
  • Modulators of the survival motor neuron (SMN) protein, offering hope for neurodegenerative conditions like Spinal Muscular Atrophy.

For researchers and procurement managers, understanding the availability and pricing of such specialized compounds is crucial. As a dedicated manufacturer in China, we aim to provide accessibility to these vital materials. We encourage you to request a quote for your research or production needs. By choosing us as your supplier, you gain access to a reliable source of high-purity 4-Trifluoromethoxyphenylboronic Acid, enabling your groundbreaking work in drug discovery and chemical synthesis.

In summary, 4-Trifluoromethoxyphenylboronic Acid is more than just a chemical intermediate; it's an enabler of innovation. Its participation in robust synthetic methodologies and its ability to confer desirable properties to target molecules make it an essential component for any serious R&D effort. We invite you to buy with confidence from a trusted manufacturer and supplier.