When sourcing 5-Aminolevulinic Acid (ALA) for your applications, you may encounter both the free base form (CAS 106-60-5) and its hydrochloride salt (CAS 5451-09-2). While both are derived from ALA and share similar core functionalities, understanding their differences is crucial for making informed purchasing decisions. As a leading manufacturer and supplier of these compounds in China, we aim to clarify these distinctions for our B2B clients.

5-Aminolevulinic Acid (Free Base):

  • Chemical Formula: C5H9NO3
  • Molecular Weight: Approximately 131.13 g/mol
  • Properties: Typically a white crystalline powder. Its solubility can vary, with good solubility in DMSO and moderate solubility in water.
  • Applications: Widely used in both pharmaceutical research and agricultural applications. Its direct use might be preferred in certain formulations where pH is a consideration or where the chloride ion is undesirable.
  • Availability: We manufacture and supply high-purity free base ALA, ensuring consistent quality for your needs.

5-Aminolevulinic Acid Hydrochloride:

  • Chemical Formula: C5H10ClNO3
  • Molecular Weight: Approximately 167.59 g/mol
  • Properties: Also a white to off-white powder. The addition of the hydrochloride group generally enhances water solubility compared to the free base, making it easier to formulate in aqueous solutions.
  • Applications: Frequently used in pharmaceutical applications, especially in photodynamic therapy (PDT) where aqueous formulations are common. Its improved solubility can simplify preparation and administration. It is also extensively researched for cancer diagnosis and treatment.
  • Availability: We also offer high-grade 5-Aminolevulinic Acid Hydrochloride, meeting strict purity requirements for pharmaceutical use.

Choosing the Right Form:

The choice between the free base and the hydrochloride salt often depends on the specific application and formulation requirements:

  • For applications requiring aqueous solubility and ease of formulation, the hydrochloride salt is often preferred.
  • If the presence of chloride ions is a concern, or if the formulation is designed for non-aqueous systems, the free base might be more suitable.

As a reliable chemical supplier, we offer both forms of ALA, allowing you to select the most appropriate one for your research and production. We provide competitive pricing for both. When you decide to purchase, our team can assist you in selecting the right product. If you need to buy 5-Aminolevulinic Acid or its salt, consult with us for quality and expertise.