In the realm of chemical synthesis, the availability of versatile building blocks is crucial for developing novel compounds and optimizing existing processes. 5-Amino-1,3,4-thiadiazole-2-thiol (CAS 2349-67-9) stands out as a key intermediate, prized for its bifunctional nature and its contribution to creating a wide array of complex molecules. This article delves into the synthetic applications of this thiadiazole derivative, highlighting its importance for researchers and manufacturers seeking high-quality chemical intermediates.

The Chemical Profile of 5-Amino-1,3,4-thiadiazole-2-thiol

With a molecular formula of C2H3N3S2 and a molecular weight of approximately 133.20 g/mol, 5-Amino-1,3,4-thiadiazole-2-thiol presents as a pale yellow to cream powder. Its insolubility in water and a high melting point (around 235°C with decomposition) are important physical characteristics for handling and reaction planning. The presence of both a nucleophilic amino group (-NH2) and a thiol group (-SH) offers multiple avenues for chemical modification and incorporation into larger molecular structures.

Key Synthetic Applications:

The utility of 5-Amino-1,3,4-thiadiazole-2-thiol in synthesis is broad, primarily revolving around its reactive functional groups:

  • Preparation of Amines: The amino group can be directly used or further derivatized, making it a convenient starting point for synthesizing substituted amines crucial in many pharmaceutical compounds.
  • Heterocyclic Ring Formation: The thiadiazole core itself is a significant structural motif in many biologically active molecules. This compound serves as an excellent precursor for building more complex fused or substituted heterocyclic systems. Researchers often buy this compound to explore novel thiadiazole-based scaffolds.
  • Nucleophilic Reactions: The thiol group (-SH) is a potent nucleophile. It readily reacts with electrophilic centers, facilitating the formation of new carbon-sulfur bonds. This property is exploited in attaching the thiadiazole moiety to various organic frameworks, often leading to molecules with unique chemical or biological properties.
  • Ligand Synthesis: Derivatives of 5-Amino-1,3,4-thiadiazole-2-thiol have been explored as ligands for metal ions, with studies showing potential in areas like coordination chemistry and catalysis.

Sourcing for Your Synthesis Projects

For chemists and formulators looking to incorporate this intermediate into their work, sourcing reliably is key. A dependable manufacturer or supplier will provide material with consistent purity, crucial for reproducible synthetic outcomes. When considering where to purchase CAS 2349-67-9, prioritizing suppliers who offer detailed technical data and responsive customer service is advisable. These suppliers often specialize in fine chemical intermediates for pharmaceutical and electronic applications, ensuring that their products meet stringent industry standards.

As a specialist in the chemical manufacturing sector, NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing high-quality 5-Amino-1,3,4-thiadiazole-2-thiol. We understand the importance of this versatile intermediate for your synthetic endeavors and are dedicated to being your trusted partner. Contact us today to inquire about pricing, availability, and to discuss how we can support your chemical synthesis needs.